Song Donetella Liu

US Patent:

6476020, Nov 5, 2002

Filed:

Sep 21, 1999

Appl. No.:

09/399018

Inventors:

Song Liu - Cincinnati OH
David Edward Portlock - Maineville OH
Schwe Fang Pong - West Chester OH

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

A61K 3155

US Classification:

51421402, 540579

Abstract:

The subject invention involves compounds having the structure: wherein the C âN , C -C , and C -C bonds are each single or double bonds, except that both C -C , and C -C are double bonds; R1 is selected from hydrogen, alkyl, aryl, and heterocycle; R2-R15 are independently selected from hydrogen and other substituents; and pharmaceutically-acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases and disorders using such compounds.

US Patent:

6566524, May 20, 2003

Filed:

Dec 21, 2001

Appl. No.:

10/027755

Inventors:

Song Liu - San Diego CA
William Martin Rennells - Schenectady NY

Assignee:

The Procter Gamble Co. - Cincinatti OH

International Classification:

C07D21702

US Classification:

546141, 546139

Abstract:

Methods of preparing an amino-substituted-tetrahydroisoquinoline-sulfonamide hydroxamic acid include the steps of providing an amino-substituted-tetrahydroisoquinoline-carboxylate attached to a solid support; reacting the ring nitrogen of the amino-tetrahydroisoquinoline-carboxylate with a sulfonyl chloride; and cleaving the intermediate from the solid support to form an amino-tetrahydroisoquinoline-sulfonamide hydroxamic acid.

US Patent:

6552033, Apr 22, 2003

Filed:

Feb 13, 2002

Appl. No.:

09/979571

Inventors:

Song Liu - San Diego CA
David Edward Portlock - Maineville OH
Schwe Fang Pong - West Chester OH

Assignee:

The Procter Gamble Co. - Cincinnati OH

International Classification:

A61K 314745

US Classification:

514292, 51421205, 514821, 514825, 546 84, 540579

Abstract:

The subject invention involves compounds having the structure: wherein each R1 is independently alkyl, aryl, or heterocycle; each R2-R7 is independently hydrogen or other substituent; B is nil and n is 0-3, or B is ethenyl and n is 0-1; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.

US Patent:

6596739, Jul 22, 2003

Filed:

Jun 14, 2002

Appl. No.:

10/149880

Inventors:

Song Liu - Cincinnati OH
Benjamin Eric Blass - Cincinnati OH
David Edward Portlock - Maineville OH

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

C07D23354

US Classification:

514341, 514398, 5483315, 5483215, 5462741

Abstract:

The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent; A is aryl or heterocycle; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.

US Patent:

6608193, Aug 19, 2003

Filed:

Dec 21, 2001

Appl. No.:

10/028227

Inventors:

Song Liu - San Diego CA
William Martin Rennells - Schenectady NY

Assignee:

The Procter Gamble Company - Cincinnati OH

International Classification:

C07D21712

US Classification:

540555, 540559, 546 62, 546 81, 546 84

Abstract:

Methods of preparing amino-substituted-tetrahydroisoquinoline ring compounds include the steps of providing a support-bound amino-substituted-tetrahydroisoquinoline compound; forming an intermediate by reacting the support-bound amino-substituted-tetrahydroisoquinoline compound with a reagent; and cyclizatively cleaving the support-bound amino-substituted-tetrahydroisoquinoline compound to form the amino-substituted-tetrahydroisoquinoline ring compound.

US Patent:

7998978, Aug 16, 2011

Filed:

Apr 19, 2007

Appl. No.:

12/299381

Inventors:

Liming Huang - San Diego CA, US
Song Liu - San Diego CA, US
Elizabeth A. Lunney - San Diego CA, US
Simon P. Planken - San Diego CA, US

Assignee:

Pfizer Inc. - Madison NJ

International Classification:

A61K 31/472

US Classification:

514310, 546143

Abstract:

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R, R, Z, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).

US Patent:

20020055637, May 9, 2002

Filed:

Dec 21, 2001

Appl. No.:

10/036671

Inventors:

Song Liu - San Diego CA, US
William Rennells - Schenectady NY, US

International Classification:

C07D215/00

US Classification:

546/152000

Abstract:

Methods of preparing an amino-substituted-tetrahydroisoquinoline-carboxylic acid include the steps of providing a support-bound amino-substituted-tetrahydroisoquinoline-carboxylate wherein the ring nitrogen has a protecting group; attaching a first moiety to the amino-substituted group of the support-bound amino-substituted-tetrahydroisoquinoline-carboxylate; de-protecting the ring nitrogen; attaching a second moiety to the ring nitrogen to form a support-bound intermediate; and cleaving the support-bound intermediate from the solid support to form the carboxylic acid.

US Patent:

20120035194, Feb 9, 2012

Filed:

Aug 8, 2011

Appl. No.:

13/204741

Inventors:

Liming Huang - San Diego CA, US
Song Liu - San Diego CA, US
Elizabeth A. Lunney - San Diego CA, US
Simon P. Planken - San Diego CA, US

Assignee:

Pfizer Inc. - Madison NJ

International Classification:

A61K 31/517
C07D 405/12
C07D 239/84
A61P 9/00
C07D 409/12
A61P 3/10
A61P 3/00
A61P 3/04
A61P 3/06
A61P 19/10
A61P 9/10
A61P 25/24
A61P 31/12
A61P 29/00
A61P 1/16
C07D 401/12

US Classification:

51426621, 5142664, 544284, 544292

Abstract:

The present invention relates to compounds of formula (I),or a pharmaceutically acceptable salt or solvate thereof, wherein: R, R, Z, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).