Stanley A Harris

US Patent:

20160042084, Feb 11, 2016

Filed:

Oct 21, 2015

Appl. No.:

14/918978

Inventors:

- Itasca IL, US
David C. KRAVITZ - Chicago IL, US
John BRASSIL - Northbrook IL, US
Kelvin G.M. BROCKBANK - Charleston SC, US
Andrew BURROUGHS - Kenosha WI, US
Douglas SCHEIN - Chicago IL, US
Stanley HARRIS - Mt. Pleasant SC, US
Dennis J. STEIBEL - Lake Zurich IL, US
Richard FRASER - Bartlett IL, US
Christopher G. CURTIS - Cardiff, GB

International Classification:

G06F 17/30
H04L 29/08

Abstract:

Methods of monitoring, maintaining, and/or restoring viability of at least one organ in a perfusion apparatus are disclosed. The methods include monitoring data comprising information relating to events occurring while at least one organ is present in a perfusion apparatus to form a data record. And they further include connecting the perfusion apparatus to a network through wiring or wirelessly, and continuously uploading the data record to a database at a location away from the perfusion apparatus in such a manner that a database computer that obtains the data record from the database can at least one of manage, track, monitor, and diagnose the at least one organ in the perfusion apparatus in real-time based upon the information in the data record.

US Patent:

20130109006, May 2, 2013

Filed:

Nov 26, 2012

Appl. No.:

13/684899

Inventors:

Lifeline Scientific, Inc. - Itasca IL, US
David C. KRAVITZ - Chicago IL, US
John BRASSIL - Northbrook IL, US
Kelvin G.M. BROCKBANK - Charleston SC, US
Andrew BURROUGHS - Kenosha WI, US
Douglas SCHEIN - Chicago IL, US
Stanley HARRIS - Mt. Pleasant SC, US
Dennis J. STEIBEL - Lake Zurich IL, US
Richard FRASER - Bartlett IL, US
Christopher G. CURTIS - Cardiff, GB

Assignee:

LIFELINE SCIENTIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

435 12, 435 11

Abstract:

Methods of monitoring, maintaining, and/or restoring viability of at least one organ in at least one device selected from an organ transporter, perfusion apparatus, cassette, and organ diagnostic apparatus, the methods including monitoring data comprising information relating to events occurring while at least one organ is present in at least one of an organ transporter, perfusion apparatus, cassette, and/or organ diagnostic apparatus to form a data record; and connecting the at least one of the organ transporter, perfusion apparatus, cassette, and/or organ diagnostic apparatus to a network through wiring or wirelessly, and uploading the data record to a database.

US Patent:

20110300611, Dec 8, 2011

Filed:

Aug 10, 2011

Appl. No.:

13/137383

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Zurich IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

LIFELINE SCIENTIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

US Patent:

20110300612, Dec 8, 2011

Filed:

Aug 10, 2011

Appl. No.:

13/137384

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Zurich IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

LIFELINE SCIENTIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

US Patent:

20110300614, Dec 8, 2011

Filed:

Aug 10, 2011

Appl. No.:

13/137386

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Forest IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

LIFELINE SCIENTIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

US Patent:

20110300615, Dec 8, 2011

Filed:

Aug 10, 2011

Appl. No.:

13/137387

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Forest IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

LIFELINE SCIENCETIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

US Patent:

20110059429, Mar 10, 2011

Filed:

Nov 5, 2010

Appl. No.:

12/926276

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Zurich IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

LIFELINE SCIENTIFIC, INC. - Itasca IL

International Classification:

A01N 1/02

US Classification:

435 12, 4352841

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

US Patent:

20110053256, Mar 3, 2011

Filed:

Nov 5, 2010

Appl. No.:

12/926277

Inventors:

Donald R. Owen - New Orleans LA, US
David C. Kravitz - Chicago IL, US
John Brassil - Northbrook IL, US
Kelvin G.M. Brockbank - Charleston SC, US
Andrew Burroughs - Kenosha WI, US
Dickon Isaacs - Chicago IL, US
Dennis J. Steibel - Lake Zurich IL, US
Richard Fraser - Bartlett IL, US
Stanley Harris - Mt. Pleasant SC, US
Douglas Schein - Chicago IL, US

Assignee:

Lifeline Scientific, Inc. - Itasca IL

International Classification:

A01N 1/02
C12M 3/00

US Classification:

4352841, 4353071, 4352871

Abstract:

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.