Steven Lewis Busch

US Patent:

61214639, Sep 19, 2000

Filed:

Jun 23, 1998

Appl. No.:

9/102869

Inventors:

Roger A. Parker - Cincinnati OH
Michael L. Edwards - Morristown NJ
Mark J. Vaal - Baltimore MD
James E. Matt - Indianapolis IN
Kim S. Chen - San Diego CA
Mark T. Yates - Ann Arbor MI
Paul S. Wright - Cincinnati OH
Steven J. Busch - Stewartsville NJ

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

C07D32700
C07D33322
C07D30500
C07D30702

US Classification:

549 4

Abstract:

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH. sub. 2). sub. m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; R. sub. 1, R. sub. 5 and R. sub. 6 are independently a C. sub. 1 -C. sub. 6 alkyl group; R. sub. 2, R. sub. 3 and R. sub. 4 are independently hydrogen or a C. sub. 1 -C. sub. 6 alkyl group; Z is thio, oxy or a methylene group; A is a C. sub. 1 -C. sub. 4 alkylene group; X is thio or oxy; and G. sub. 1 and G. sub. 2 are independently hydrogen, C. sub. 1 -C. sub. 6 alkyl or --C(O)--(CH. sub. 2). sub. n --CH. sub. 3 and n is an integer 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.

US Patent:

60596597, May 9, 2000

Filed:

Jun 6, 1997

Appl. No.:

8/870280

Inventors:

Steven L. Busch - Liverpool NY
Charles S. Zussman - Egg Harbor Township NJ
Thomas R. Wein - Mason OH
Stefan Giselbrecht - Graz, AT
Peter Hodl - Graz, AT
Franz Lechner - Graz, AT

Assignee:

Las Vegas Gaming, Inc. - Las Vegas NV

International Classification:

A63F 500

US Classification:

463 17

Abstract:

Method of playing roulette with a system including a roulette wheel, a conventional betting layout and a progressive jackpot layout. Players make wages on the conventional layout and/or the progressive layout to participate in a progressive jackpot game wherein the jackpot is accumulated from losing wagers on the progressive jackpot layout. The system includes sensors for detecting chips placed on the progressive layout. The jackpot is won by a wagered winning number being selected by the roulette wheel in a predetermined number of successive spins.

US Patent:

57958769, Aug 18, 1998

Filed:

Mar 25, 1997

Appl. No.:

8/824221

Inventors:

Paul S. Wright - Cincinnati OH
Steven J. Busch - West Chester OH

Assignee:

Hoechst Marion Rousssel, Inc. - Cincinnati OH

International Classification:

A61K 31695

US Classification:

514 63

Abstract:

Methods useful for inhibiting VCAM-1 and for treating chronic inflammatory conditions in a patient in need thereof are disclosed comprising administering to the patient effective amounts of a compound of the formula ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are each independently a C. sub. 1 -C. sub. 6 alkyl group; Z is a thio, oxy or methylene group; A is a C. sub. 1 -C. sub. 4 alkylene group; R. sub. 5 is a C. sub. 1 -C. sub. 6 alkyl or --(CH. sub. 2). sub. n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C. sub. 1 -C. sub. 6 alkyl; are disclosed.

US Patent:

61145726, Sep 5, 2000

Filed:

Nov 19, 1997

Appl. No.:

8/974112

Inventors:

Roger A. Parker - Cincinnati OH
Paul S. Wright - Cincinnati OH
Steven J. Busch - Stewartsville NJ
Kim S. Chen - San Diego CA
Mark T. Yates - Ann Arbor MI

Assignee:

Hoechst Marion Roussel, Inc. - Bridgewater NJ

International Classification:

C07C 6702
C07C 5900
C07C 4100
A01N 3100

US Classification:

560254

Abstract:

The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH. sub. 2). sub. m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; R. sub. 1 is C. sub. 1 -C. sub. 6 alkyl; and R. sub. 2, R. sub. 3 and R. sub. 4 are each independently hydrogen or C. sub. 1 -C. sub. 6 alkyl; or a stereoisomer thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.

US Patent:

54608074, Oct 24, 1995

Filed:

Jun 15, 1993

Appl. No.:

8/077891

Inventors:

Alan D. Cardin - Cincinnati OH
Steven J. Busch - West Chester OH
Masayuki Mano - Izumo, JP

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 31785
A61K 31795
C08G 7102

US Classification:

424 781

Abstract:

The oligomers of the present invention are polyureas or polyamides having a number average molecular weight of

US Patent:

56080956, Mar 4, 1997

Filed:

Apr 30, 1996

Appl. No.:

8/637968

Inventors:

Roger A. Parker - Cincinnati OH
Michael L. Edwards - Cincinnati OH
Mark J. Vaal - Cincinnati OH
James E. Matt - Cincinnati OH
Kim S. Chen - Cincinnati OH
Mark T. Yates - Ann Arbor MI
Paul S. Wright - Cincinnati OH
Steven J. Busch - West Chester OH

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

C07F 708
C07F 710
C07F 718

US Classification:

556413

Abstract:

This invention relates to compounds of the formula ##STR1## wherein R. sub. 1 and R. sub. 6 are each independently C. sub. 1 -C. sub. 6 alkyl; R. sub. 2, R. sub. 3 and R. sub. 4 are each independently hydrogen or C. sub. 1 -C. sub. 6 alkyl; R is hydrogen or --C(O)--(CH. sub. 2). sub. m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; Z is a thio, oxy or methylene group; A is a C. sub. 1 -C. sub. 4 alkylene group; R. sub. 5 and R. sub. 7 are each independently a C. sub. 1 -C. sub. 6 alkyl or --(CH. sub. 2). sub. n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, halogen, trifluoromethyl, C. sub. 1 -C. sub. 6 alkyl, or --NR. sub. 8 R. sub. 9, wherein R. sub. 8 and R. sub.