Steven R Mickelsen

US Patent:

20220323739, Oct 13, 2022

Filed:

Jun 27, 2022

Appl. No.:

17/850174

Inventors:

- Iowa City IA, US
Steven Richard Mickelsen - Iowa CIty IA, US

International Classification:

A61M 39/10
A61B 5/0538
A61B 5/00
A61B 18/14
A61B 18/12
A61M 25/01
A61M 25/06
A61B 34/00
A61M 25/09

Abstract:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

US Patent:

20210031020, Feb 4, 2021

Filed:

May 15, 2020

Appl. No.:

16/875076

Inventors:

- Iowa City IA, US
Steven Richard MICKELSEN - Iowa City IA, US

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

A61M 39/10
A61B 5/053
A61B 5/00
A61B 18/14
A61B 18/12
A61M 25/01
A61M 25/06
A61B 34/00
A61M 25/09

Abstract:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

US Patent:

20200038104, Feb 6, 2020

Filed:

Oct 7, 2019

Appl. No.:

16/595224

Inventors:

- Menlo Park CA, US
Steven R. MICKELSEN - Iowa City IA, US

Assignee:

Farapulse, Inc. - Menlo Park CA

International Classification:

A61B 18/14
A61B 18/12

Abstract:

Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.

US Patent:

20180200497, Jul 19, 2018

Filed:

Mar 9, 2018

Appl. No.:

15/917194

Inventors:

- Iowa City IA, US
Steven Richard MICKELSEN - Iowa City IA, US

International Classification:

A61M 39/10
A61M 25/06
A61B 5/053
A61B 5/00
A61B 18/12
A61B 18/14
A61M 25/01
A61B 18/00
A61B 17/00
A61B 18/20
A61M 25/00
A61B 18/02
A61B 17/22
A61B 34/00
A61B 18/18

Abstract:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

US Patent:

20180093088, Apr 5, 2018

Filed:

Nov 21, 2017

Appl. No.:

15/819726

Inventors:

- Iowa City IA, US
Steven Richard Mickelsen - Iowa City IA, US

International Classification:

A61M 39/10
A61M 25/06
A61B 5/053
A61B 5/00
A61B 18/12
A61B 18/14
A61M 25/01
A61B 18/00
A61B 17/00
A61B 18/20
A61M 25/00
A61B 18/02
A61B 17/22
A61B 18/18

Abstract:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

US Patent:

20180042674, Feb 15, 2018

Filed:

Oct 26, 2017

Appl. No.:

15/795062

Inventors:

- Menlo Park CA, US
Steven Richard MICKELSEN - Iowa City IA, US

International Classification:

A61B 18/14
A61B 5/053
A61N 1/32
A61N 7/02
A61B 18/12
A61N 1/04
A61B 5/0408
A61B 17/00
A61B 18/18
A61B 5/044
A61B 18/00

Abstract:

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

US Patent:

20170151029, Jun 1, 2017

Filed:

Oct 3, 2016

Appl. No.:

15/283667

Inventors:

- Iowa City IA, US
Steven Richard Mickelsen - Iowa City IA, US

Assignee:

UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA

International Classification:

A61B 34/00
A61M 25/09
A61M 25/06
A61B 18/14
A61M 25/01

Abstract:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

US Patent:

20170065339, Mar 9, 2017

Filed:

Nov 2, 2016

Appl. No.:

15/341512

Inventors:

- Menlo Park CA, US
Steven R. MICKELSEN - Iowa City IA, US

International Classification:

A61B 18/14
A61N 1/32
A61N 7/02
A61B 5/053

Abstract:

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.