Steven W Mitchell

US Patent:

7309585, Dec 18, 2007

Filed:

May 9, 2005

Appl. No.:

11/125805

Inventors:

Pia M. Challita-Eid - Encino CA, US
Rene S. Hubert - Los Angeles CA, US
Steven Chappell Mitchell - Gurnee IL, US
Arthur B. Raitano - Los Angeles CA, US
Mary Faris - Los Angeles CA, US
Daniel E. H. Afar - Pacific Palisades CA, US
Aya Jakobovits - Beverly Hills CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

C12P 21/06
C12N 1/20
C12N 15/00
C07H 21/04

US Classification:

435 691, 435455, 4352523, 4353201, 536 235

Abstract:

A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

US Patent:

7319006, Jan 15, 2008

Filed:

May 28, 2004

Appl. No.:

10/856109

Inventors:

Daniel E. Afar - Pacific Palisades CA, US
Rene S. Hubert - Los Angeles CA, US
Arthur B. Raitano - Los Angeles CA, US
Douglas Saffran - Encinitas CA, US
Steven Chappell Mitchell - Gurnee IL, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (ix ransmembrane pithelial ntigen of the rostate). Four particular human STEAP's are described and characterized herein. The human STEAP's exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

US Patent:

7351583, Apr 1, 2008

Filed:

Nov 16, 2004

Appl. No.:

10/991028

Inventors:

Arthur B. Raitano - Los Angeles CA, US
Daniel E. H. Afar - Pacific Palisades CA, US
Aya Jakobovits - Beverly Hills CA, US
Mary Faris - Los Angeles CA, US
Rene S. Hubert - Los Angeles CA, US
Steven Chappell Mitchell - Gurnee IL, US
Douglas Saffran - Encinitas CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

C12N 15/85

US Classification:

435326, 435328, 435330, 5303871, 5303873, 5303877, 5303879

Abstract:

A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.

US Patent:

7496525, Feb 24, 2009

Filed:

Mar 17, 2000

Appl. No.:

09/528466

Inventors:

Steven R Mitchell - Manhattan Beach CA, US

International Classification:

G06Q 30/00

US Classification:

705 26, 705 27

Abstract:

A method of doing business on the internet by which the manufacturer maintains an on-line presence without bypassing and without alienating the retailer and the distributor such that the manufacturer, distributor and independent retailer all share in the profits of on-line sales. The method employs a purchase coordinator that provides participating retailers with web sites affiliated with the manufacturer. The purchase coordinator obtains product data and price data from the manufacturer, distributor and retailer; receives orders from internet customers; selects a distributor to fill the order; and processes a monetary transaction for the order such that the distributor, retailer, and the manufacturers are each credited with a sum representing their portion of the total value of the order according to the price data.

US Patent:

7569356, Aug 4, 2009

Filed:

Nov 18, 2004

Appl. No.:

10/992946

Inventors:

Daniel E. H. Afar - Pacific Palisades CA, US
Rene S. Hubert - Los Angeles CA, US
Arthur B. Raitano - Los Angeles CA, US
Steven Chappell Mitchell - Gurnee IL, US
Mary Faris - Los Angeles CA, US
Aya Jakobovits - Beverly Hills CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

G01N 33/574

US Classification:

435 723, 530350, 5303871, 5303877, 5303888, 5303897, 436 64

Abstract:

The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.

US Patent:

7575749, Aug 18, 2009

Filed:

Jun 1, 2004

Appl. No.:

10/858887

Inventors:

Daniel E. Afar - Pacific Palisades CA, US
Rene S. Hubert - Los Angeles CA, US
Kahan Leong - Playa Del Rey CA, US
Arthur B. Raitano - Los Angeles CA, US
Douglas Saffran - Encinitas CA, US
Steven Chappell Mitchell - Gurnee IL, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

A61K 39/38

US Classification:

4241841

Abstract:

Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer.

US Patent:

7582448, Sep 1, 2009

Filed:

Nov 7, 2006

Appl. No.:

11/594275

Inventors:

Aya Jakobovits - Beverly Hills CA, US
Daniel E. H. Afar - Pacific Palisades CA, US
Pia M. Challita-Eid - Encino CA, US
Elena Levin - Los Angeles CA, US
Steven Chappell Mitchell - Gurnee IL, US
Rene S. Hubert - Los Angeles CA, US

Assignee:

Agensys, Inc. - Santa Monica CA

International Classification:

C07H 21/02

US Classification:

435 692, 536 231

Abstract:

A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

US Patent:

7727533, Jun 1, 2010

Filed:

May 28, 2004

Appl. No.:

10/857785

Inventors:

Daniel E. Afar - Pacific Palisades CA, US
Rene S. Hubert - Los Angeles CA, US
Arthur B. Raitano - Los Angeles CA, US
Douglas Saffran - Encinitas CA, US
Steven Chappell Mitchell - Gurnee IL, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/00

US Classification:

4241841

Abstract:

Described is a family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (ix ransmembrane pithelial ntigen of the rostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family is STEAP-1, which appears to be a type IIIa membrane protein. STEAP-1 is a 339 amino acid protein. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.