Steven B Rosen

US Patent:

6365365, Apr 2, 2002

Filed:

Nov 12, 1998

Appl. No.:

09/190911

Inventors:

Annette Bistrup - San Francisco CA
Steven D. Rosen - San Francisco CA
Kirsten Tangemann - Menlo Park CA
Stefan Hemmerich - Berkeley CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 148

US Classification:

435 15, 435 14, 435194, 536 231, 530350

Abstract:

A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof.

US Patent:

6380371, Apr 30, 2002

Filed:

Sep 13, 1999

Appl. No.:

09/394645

Inventors:

Christopher M. Sassetti - Richmond CA
Steven D. Rosen - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 2104

US Classification:

536 231, 536 235, 530380, 530350

Abstract:

Nucleic acid compositions encoding novel endoglycan proteins, as well as the novel endoglycan proteins, are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with endoglycan activity. In particular, methods of treating diseases associated with endoglycan selectin binding activity and/or chemokine presenting activity are provided, where such diseases include inflammation and the like.

US Patent:

6395882, May 28, 2002

Filed:

Feb 3, 1999

Appl. No.:

09/243560

Inventors:

Steven D. Rosen - San Francisco CA
Christopher M. Sassetti - Richmond CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 14705

US Classification:

530395, 530350

Abstract:

Podocalyxin like proteins (e. g. PCLP and PCLP-2) having selectin ligand activity are provided. Also provided are nucleic acid compositions encoding novel PCLP-2 proteins. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with podocalyxin like protein activity. In particular, methods of treating diseases associated with podocalyxin like protein selectin binding activity and/or chemokine presenting activity are provided, where such diseases include inflammation and the like.

US Patent:

6844175, Jan 18, 2005

Filed:

Nov 8, 2001

Appl. No.:

10/007262

Inventors:

Annette Bistrup - San Francisco CA, US
Steven D. Rosen - San Francisco CA, US
Kirsten Tangemann - Menlo Park CA, US
Stefan Hemmerich - Berkeley CA, US

Assignee:

The Regents of the University of the California - Oakland CA
Syntex (U.S.A.) INC - Palo Alto CA

International Classification:

C12N 910
C12Q 148
C07K 14435
C07H 2102

US Classification:

435193, 435 15, 530408, 536 232

Abstract:

A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof.

US Patent:

6852518, Feb 8, 2005

Filed:

Jun 13, 2000

Appl. No.:

09/593828

Inventors:

Steven D. Rosen - San Francisco CA, US
Jin Kyu Lee - Alameda CA, US
Stefan Hemmerich - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA
Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C12N009/10
C12N015/00
C12N005/00
C12N001/20
C07H021/04

US Classification:

435193, 4353201, 435325, 4352523, 435 6, 536 232

Abstract:

Novel glycosylsulfotransferases (GST-4α, GST-4β, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4α, GST-4β, and GST-6.

US Patent:

6933142, Aug 23, 2005

Filed:

Aug 23, 2000

Appl. No.:

09/645078

Inventors:

Annette Bistrup - San Francisco CA, US
Steven D. Rosen - San Francisco CA, US
Stefan Hemmerich - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA
Syntex (USA), LLC - Palo Alto CA

International Classification:

C12N009/10
C07K014/435

US Classification:

435193, 530395

Abstract:

Mammalian glycosylsulfotransferases expressed in high endothelial cells (HEC-GLCNAC6ST) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of HEC-GLCNAC6ST or KSGal6ST, or homologues thereof.

US Patent:

6967093, Nov 22, 2005

Filed:

Mar 22, 2001

Appl. No.:

09/816825

Inventors:

Annette Bistrup - San Francisco CA, US
Steven D. Rosen - San Francisco CA, US
Stefan Hemmerich - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA
Syntex (U.S.A) LLC - Palo Alto CA

International Classification:

C12P021/06
C12N009/00
C12N009/10
C07H021/04

US Classification:

435193, 435 4, 435 6, 435 691, 435183, 435192, 4352523, 4353201, 435325, 536 232, 536 235

Abstract:

A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith.

US Patent:

7070971, Jul 4, 2006

Filed:

Oct 29, 2003

Appl. No.:

10/697828

Inventors:

Steven Rosen - San Francisco CA, US
Jin Kyu Lee - Alameda CA, US
Stefan Hemmerich - Berkeley CA, US

Assignee:

Syntex (U.S.A.), LLC - Palo Alto CA
The Regents of the University of California - Oakland CA

International Classification:

C12N 9/10
C12N 15/00
C12N 1/20
C07K 1/00
C12Q 1/68

US Classification:

435193, 530350, 4353201, 4352523, 435 6

Abstract:

Novel glycosylsulfotransferases (GST-4α, GST-4β, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4α, GST-4β, and GST-6.