Stote L Ellsworth

US Patent:

20120020980, Jan 26, 2012

Filed:

Jun 16, 2011

Appl. No.:

13/162497

Inventors:

LAWRENCE M. KAUVAR - SAN FRANCISCO CA, US
STOTE ELLSWORTH - PALO ALTO CA, US
WILLIAM USINGER - LAFAYETTE CA, US
KRISTA MAUREEN MCCUTCHEON - BURLINGAME CA, US
YING-PING JIANG - LAFAYETTE CA, US
FEN ZHANG - SAN FRANCISCO CA, US
BO CHEN - DALY CITY CA, US
GIZETTE SPERINDE - SAN FRANCISCO CA, US
MINHA PARK - BRISBANE CA, US
ORIT FOORD - FOSTER CITY CA, US

Assignee:

TRELLIS BIOSCIENCE, INC. - SOUTH SAN FRANCISCO CA

International Classification:

A61K 39/42
C12N 5/10
A61P 31/20
C12P 21/08
C07K 16/08
C12N 15/13
C12N 1/00

US Classification:

4241421, 536 2353, 435339, 435243, 435419, 435 696, 53038815, 5303873

Abstract:

Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20120020971, Jan 26, 2012

Filed:

Jun 17, 2011

Appl. No.:

13/163489

Inventors:

Lawrence M. KAUVAR - San Francisco CA, US
Stote Ellsworth - Palo Alto CA, US
William Usinger - Lafayette CA, US
Krista M. McCutcheon - Burlingame CA, US
Minha Park - Brisbane CA, US
Bo Chen - Daly City CA, US
Ying-Ping Jiang - Lafayette CA, US

Assignee:

Trellis Bioscience, Inc. - South San Francisco CA

International Classification:

A61K 39/42
A61P 31/00
C12N 5/10
C12N 15/85
C12P 21/08
C07K 16/10
A61P 31/16

US Classification:

4241361, 5303883, 5303873, 53038815, 4241471, 4353201, 435 696, 435366

Abstract:

Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

US Patent:

20170204165, Jul 20, 2017

Filed:

Mar 20, 2017

Appl. No.:

15/464165

Inventors:

- Menlo Park CA, US
Stote ELLSWORTH - Palo Alto CA, US
William USINGER - Lafayette CA, US
Krista Maureen MCCUTCHEON - Burlingame CA, US
Ying-Ping JIANG - Lafayette CA, US
Fen ZHANG - San Francisco CA, US
Bo CHEN - Daly City CA, US
Gizette SPERINDE - El Granada CA, US
Minha PARK - Brisbane CA, US
Orit FOORD - Foster City CA, US

Assignee:

Trellis Bioscience, LLC - Menlo Park CA

International Classification:

C07K 16/08

Abstract:

Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20150252099, Sep 10, 2015

Filed:

Apr 27, 2015

Appl. No.:

14/697459

Inventors:

- MENLO PARK CA, US
Stote ELLSWORTH - Palo Alto CA, US
William USINGER - Lafayette CA, US
Krista Maureen MCCUTCHEON - Burlingame CA, US
Ying-Ping JIANG - Lafayette CA, US
Fen ZHANG - San Francisco CA, US
Bo CHEN - Daly City CA, US
Gizette SPERINDE - El Granada CA, US
Minha PARK - Brisbane CA, US
Orit FOORD - Foster City CA, US

International Classification:

C07K 16/08
A61K 39/245
C07K 16/46

Abstract:

Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

US Patent:

20140322210, Oct 30, 2014

Filed:

Dec 5, 2012

Appl. No.:

14/363297

Inventors:

- South San Francisco CA, US
Stote Ellsworth - Palo Alto CA, US
William Usinger - Lafayette CA, US
Krista Maureen McCutcheon - Burlingame CA, US
Minha Park - Brisbane CA, US

International Classification:

C07K 16/10

US Classification:

4241331, 53038815, 5303873, 4241421, 4353201, 435 696, 435339, 435328

Abstract:

Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.