Subhra S Bhattacharya

US Patent:

20030072715, Apr 17, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/922407

Inventors:

Benjamin Frydman - Madison WI, US
Manfred Hesse - Binz, CH
Armin Guggisberg - Schlieren, CH
Kasim Popaj - Schlieren, CH
Konstantin Drandarov - Zurich, CH
Hirak Basu - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US

International Classification:

A61K049/00
C07D245/00
C07F005/00

US Classification:

424/009363, 540/460000, 534/015000

Abstract:

Novel cyclic polyamine compounds of the form where A, each A(if present), and Aare independently selected from C-Calkyl, where each Y is independently selected from H or C-Calkyl, where M is selected from C-Calkyl, where k is 0, 2, or 3, and where R is selected from C-Calkyl, as well as all stereoisomers and salts thereof, are disclosed. Additional compounds where k is 1 and Ais independently selected from C-Calkyl or C-Calkyl are also disclosed. Cyclic polyamines, where the amide group is reduced to a secondary amino group, and various derivatives of these compounds, are also described. Synthetic methods for the compounds are described. The compounds are useful for treating diseases caused by uncontrolled proliferation of cells, such as cancer, especially prostate cancer, and for inducing intracellular ATP hydrolysis for treatment of other disorders.

US Patent:

20040152687, Aug 5, 2004

Filed:

Jun 24, 2003

Appl. No.:

10/606016

Inventors:

Benjamin Frydman - Madison WI, US
Venodhar Reddy - Madison WI, US
Hirak Basu - Madison WI, US
Aparajita Sarkar - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US
Laurence Marton - Palo Alto CA, US
Andrei Blokhin - Fitchburg WI, US

International Classification:

A61K031/555
C07D487/22
A61K031/409

US Classification:

514/185000, 514/410000, 540/145000

Abstract:

Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.

US Patent:

20050130949, Jun 16, 2005

Filed:

Jan 27, 2005

Appl. No.:

11/046344

Inventors:

Benjamin Frydman - Madison WI, US
Manfred Hesse - Binz, CH
Armin Guggisberg - Schlieren, CH
Kasim Popaj - Schlieren, CH
Konstantin Drandarov - Zurich, CH
Hirak Basu - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US

International Classification:

C07D245/02
A61K031/506

US Classification:

514183000, 540460000

Abstract:

Novel cyclic polyamine compounds of the form

US Patent:

20060276444, Dec 7, 2006

Filed:

Feb 7, 2006

Appl. No.:

11/350308

Inventors:

Benjamin Frydman - Madison WI, US
Linda Clifford - Madison WI, US
Aldonia Valasinas - Buenos Aires, AR
Venodhar Reddy - Madison WI, US
Hirak Basu - Madison WI, US
Aparajita Sarkar - Madison WI, US
Subhra Bhattacharya - Madison WI, US
Yu Wang - Madison WI, US
Laurence Marton - Palo Alto CA, US
Andrei Blokhin - Madison WI, US

International Classification:

A61K 31/409
A61K 31/555

US Classification:

514185000, 514410000

Abstract:

Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.