Tejinder Ahluwalia Kiranjit K Singh

US Patent:

20060199175, Sep 7, 2006

Filed:

Mar 7, 2005

Appl. No.:

11/072337

Inventors:

Rama Kristipati - Fremont CA, US
Tejinder Singh - Palo Alto CA, US
Thelma Dunnebacke - Berkeley CA, US
Anthony Caldwell - Frankfort IN, US

International Classification:

C12Q 1/70
G01N 33/569
G01N 33/554
G01N 33/53

US Classification:

435005000, 435007220, 435007320

Abstract:

The present invention discloses a quick, simple, qualitative and semi-quantitative immunologic method and device in a field test kit format for the detection and the stage of infection of certain protozoal, viral, bacterial, or nematodal pathogens in body fluids, using vaccines specific to such pathogens as antigens. The method comprises immobilizing an antigen specific to a selected protozoal, bacterial, viral or nematodal pathogen on a support membrane, obtaining a sample of a body fluid from a human or animal suspected of harboring the pathogen, thus containing antibodies thereto, contacting the antigen with the sample of body fluid and detecting the binding of the antigen with the antibodies by any suitable means. The device comprises a rigid member, an absorbent layer, a foam layer and a support member on which the antigen is immobilized, glued together to form a compact assembly. The field test kit comprises the device enclosed in a casing and vials containing additional reagents such as washing and dilution buffers, a chromogenic label for the detection of the antigen-antibody complex and positive and negative control solutions to verify the accuracy of the tests, instructions for use and the like. All the components are packaged in a small plastic container or box for easy transportation and use. While this invention is particularly adaptable to the detection of using its vaccine as an antigen, other pathogens can also be detected by the method of this invention. These include but are not limited to and other similar organisms.

US Patent:

53648420, Nov 15, 1994

Filed:

Jun 23, 1993

Appl. No.:

8/081863

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor C. Gohil - Richmond CA
Karen L. Valentino - San Carlos CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3700
A61K 3702
C07K 500
C07K 700

US Classification:

514 12

Abstract:

A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit voltage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega-conopeptide MVIIA binding sites present in neuronal tissue.

US Patent:

61367869, Oct 24, 2000

Filed:

Sep 9, 1999

Appl. No.:

9/392979

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor Chandra Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 3800
A61K 3900
A61K 3938
C07K 500
C07K 700

US Classification:

514 12

Abstract:

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

US Patent:

58246452, Oct 20, 1998

Filed:

Nov 1, 1996

Appl. No.:

8/742774

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor Chandra Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3800
A61K 3802
C07K 500
C07K 700

US Classification:

514 12

Abstract:

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

US Patent:

59943050, Nov 30, 1999

Filed:

Aug 21, 1998

Appl. No.:

9/138439

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor Chandra Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 3800
C07K 700
G01N 3300
G01N 3348

US Classification:

514 12

Abstract:

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

US Patent:

60870915, Jul 11, 2000

Filed:

Apr 23, 1999

Appl. No.:

9/298017

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor Chandra Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 100
G01N 3353
A61K 3800

US Classification:

435 4

Abstract:

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

US Patent:

55874541, Dec 24, 1996

Filed:

Apr 15, 1993

Appl. No.:

8/049794

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor C. Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3800
C07K 500
C07K 700
C07K 1700

US Classification:

530324

Abstract:

Disclosed are novel omega conotoxin peptides effective in producing analgesia.

US Patent:

58591869, Jan 12, 1999

Filed:

Jul 3, 1996

Appl. No.:

8/675354

Inventors:

Alan Justice - Sunnyvale CA
Tejinder Singh - Palo Alto CA
Kishor Chandra Gohil - Richmond CA
Karen L. Valentino - San Carlos CA
George P. Miljanich - Redwood City CA

Assignee:

Neurex Corporation - Menlo Park CA

International Classification:

A61K 3800
C07K 500
C07K 700

US Classification:

530324

Abstract:

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.