Thanh Thuy Thi Le

US Patent:

8111402, Feb 7, 2012

Filed:

Apr 3, 2009

Appl. No.:

12/418525

Inventors:

Thanh M. Le - Duarte CA, US
Nan Yu - Arcadia CA, US
Anatoliy Savchenkov - Glendale CA, US
William H. Steier - San Marino CA, US

Assignee:

OEwaves, Inc. - Pasadena CA
California Institute of Technology - Pasadena CA
University of Southern California - Los Angeles CA

International Classification:

G01B 9/02

US Classification:

356491, 356480

Abstract:

Techniques and devices based on transverse magnetic (TM) and transverse electric (TE) modes in an optical resonator or interferometer to provide sensitive optical detection with insensitivity to a change in temperature. A shift in a difference between a first resonance wavelength of a TE optical mode and a second resonance wavelength of a TM optical mode is measured to measure a change in a sample that is in optical interaction with the optical resonator or interferometer. For example, the detected shift can be used to measure a change in a refractive index of the sample.

US Patent:

8124927, Feb 28, 2012

Filed:

May 29, 2007

Appl. No.:

11/754959

Inventors:

Anatoliy Savchenkov - La Crescenta CA, US
Makan Mohageg - Valley Village CA, US
Thanh M. Le - Duarte CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G02B 6/26
G02B 6/42
G02F 1/035

US Classification:

25022724, 385 30

Abstract:

An optical device including a whispering gallery mode (WGM) optical resonator configured to support one or more whispering gallery modes; and a photodetector optically coupled to an exterior surface of the optical resonator to receive evanescent light from the optical resonator to detect light inside the optical resonator.

US Patent:

8167932, May 1, 2012

Filed:

Oct 18, 2005

Appl. No.:

11/252657

Inventors:

Henry Bourang - Irvine CA, US
Thanh Huy Le - Oceanside CA, US
David M. Taylor - Lake Forest CA, US
Sam Sok - Santa Ana CA, US
Mario Iobbi - Agoura Hills CA, US
Rajesh Khanna - Tustin CA, US
Dave J. Evans - Irvine CA, US

Assignee:

Edwards Lifesciences Corporation - Irvine CA

International Classification:

A61F 2/24
A61F 2/06

US Classification:

623 211, 623 111

Abstract:

A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a delivery sleeve. A step balloon protrudes from the delivery sleeve and provides a tapered surface for facilitating advancement through a body vessel. The step balloon also aids in crossing the leaflets of a native valve. After the prosthetic valve is positioned within the native valve, the delivery sleeve is retracted to expose the prosthetic valve. In one embodiment, the delivery sleeve is retracted by the use of a lead screw, which effectuates relative movement between the valve catheter and delivery sleeve. The prosthetic valve is preferably self-expandable. If necessary, the step balloon may be expanded to securely seat the prosthetic valve at the site of the native valve. The prosthetic valve is preferably coupled to the valve catheter by a plurality of flexible extension arms which allow the prosthetic valve to be collapsed after initial deployment such that the prosthetic valve may be repositioned if necessary.

US Patent:

20120290078, Nov 15, 2012

Filed:

Apr 17, 2012

Appl. No.:

13/449200

Inventors:

Henry Bourang - Irvine CA, US
Thanh Huy Le - Oceanside CA, US
David M. Taylor - Lake Forest CA, US
Sam Sok - Santa Ana CA, US
Mario Iobbi - Agoura Hills CA, US
Rajesh Khanna - Morrisdale CA, US
Dave J. Evans - Irvine CA, US

Assignee:

EDWARDS LIFESCIENCES CORPORATION - Irvine CA

International Classification:

A61F 2/24

US Classification:

623 211

Abstract:

A heart valve delivery system is provided wherein a prosthetic valve is carried on a valve catheter inside a tubular delivery sleeve. The valve catheter has a distal end coupled to a mop. The mop comprises a plurality of flexible extensions configured for releasable attachment to the prosthetic valve. A lead screw nut is coupled to a proximal end of the tubular delivery sleeve and a lead screw is coupled to the valve catheter. The lead screw engages the lead screw nut and rotation of the lead screw causes the delivery sleeve to retract relative to the valve catheter and the prosthetic valve for exposing the prosthetic valve. The flexible extensions of the mop allow expansion of the valve while maintaining the attachment during placement of the valve at a native valve site.

US Patent:

20230103353, Apr 6, 2023

Filed:

Dec 13, 2022

Appl. No.:

18/080043

Inventors:

- Irvine CA, US
Kristen Hicks - Irvine CA, US
Gil Senesh - Laguna Beach CA, US
Michael R. Bialas - Lake Forest CA, US
Tung T. Le - Costa Mesa CA, US
Sean Chow - Irvine CA, US
Thanh Huy Le - Oceanside CA, US

International Classification:

A61F 2/24

Abstract:

Devices and methods for crimping a prosthetic heart valve onto a delivery device are described. In some embodiments, valves are crimped over an inflatable balloon and between proximal and distal shoulders mounted on a shaft inside the balloon. Crimping methods can include multiple compression steps with the valve located in different axial positions relative to the crimping jaws at each different step. In some methods, the valve may extend partially outside of the crimping jaws during certain crimping steps, such that the crimping force is only applied to the part of the valve that is inside the jaws. Exemplary crimping devices can include two or more adjacent sets of jaws that close down to different inner diameters, such that different parts of a valve get compressed to different outer diameters at the same time during a single crimping step.

US Patent:

20200214840, Jul 9, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/820499

Inventors:

- Irvine CA, US
Tung T. Le - Costa Mesa CA, US
Thanh Huy Le - Oceanside CA, US
Brian C. Gray - Trabuco Canyon CA, US
Alejandro J. Froimovich Rosenberg - Sherman Oaks CA, US
Jeff Lindstrom - Coto de Caza CA, US
Kim D. Nguyen - Irvine CA, US
Sonny Tran - Westminster CA, US

International Classification:

A61F 2/24

Abstract:

A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.

US Patent:

20190029820, Jan 31, 2019

Filed:

Oct 2, 2018

Appl. No.:

16/149947

Inventors:

- Irvine CA, US
Yong GAO - Irvine CA, US
Erik BULMAN - Lake Forest CA, US
Baigui BIAN - Irvine CA, US
Yidong M. ZHU - Irvine CA, US
David D. WILLIAMS - Bountiful UT, US
Timothy A. GEISER - Laguna Niguel CA, US
Michael G. VALDEZ - Riverside CA, US
Sonny TRAN - Westminster CA, US
Richard D. WHITE - Poway CA, US
Thanh Huy LE - Oceanside CA, US
Tung T. LE - Irvine CA, US
Alpana K. GOWDAR - Newport Beach CA, US

International Classification:

A61F 2/24
A61M 25/06
A61M 25/00
A61M 25/01
A61F 2/97

Abstract:

An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.

US Patent:

20170065415, Mar 9, 2017

Filed:

Aug 30, 2016

Appl. No.:

15/252110

Inventors:

- Irvine CA, US
Tung T. Le - Irvine CA, US
Thanh Huy Le - Oceanside CA, US
Brian C. Gray - Lake Forest CA, US
Alejandro J. Froimovich Rosenberg - Sherman Oaks CA, US
Jeff Lindstrom - Coto de Caza CA, US
Kim D. Nguyen - Irvine CA, US
Sonny Tran - Westminster CA, US

International Classification:

A61F 2/24

Abstract:

A delivery apparatus for implanting a radially compressible and expandable prosthetic heart valve in a native heart valve of the heart includes a handle portion and an elongated shaft extending from and movable relative to the handle portion. The shaft includes a proximal end portion coupled to the handle portion and a distal end portion configured to mount a prosthetic heart valve in a radially compressed state. The handle portion includes a control member movable longitudinally with respect to the handle portion, the control member engaging a gear assembly operable to convert longitudinal motion of the control member to rotational motion of the gear assembly. The gear assembly engages the elongated shaft such that rotational motion of the gear assembly causes corresponding longitudinal motion of the elongated shaft relative to the handle portion.