Thomas J Moon

US Patent:

20100183524, Jul 22, 2010

Filed:

Nov 20, 2009

Appl. No.:

12/623132

Inventors:

Jan Zielinski - Vista CA, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

Assignee:

Perio Sciences, LLC - Dallas TX

International Classification:

A61K 8/36
A61K 8/33
A61Q 11/00

US Classification:

424 55, 424 49

Abstract:

One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrocurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrocurcuminoids CG™, or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above.

US Patent:

20110077275, Mar 31, 2011

Filed:

Jul 27, 2010

Appl. No.:

12/844313

Inventors:

Jan Zielinski - Vista CA, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

International Classification:

A61K 31/465
A61P 39/06
A61P 1/02

US Classification:

514343

Abstract:

One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrcurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrcurcuminoids CG™, or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above.

US Patent:

20140050675, Feb 20, 2014

Filed:

Oct 23, 2013

Appl. No.:

14/061227

Inventors:

Jan Zielinski - Vista CA, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

International Classification:

A61K 31/192
A61K 45/06
A61Q 11/00
A61K 31/045
A61K 31/05
A61K 8/19
A61K 31/12
A61K 31/047

US Classification:

424 52, 514570

Abstract:

One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrcurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrcurcuminoids CG™, or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above.

US Patent:

20160331707, Nov 17, 2016

Filed:

Jul 28, 2016

Appl. No.:

15/222570

Inventors:

- Dallas TX, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

International Classification:

A61K 31/192
A61K 45/06
A61K 47/10
A61K 9/00
A61K 31/12

Abstract:

One embodiment of the invention is directed to a method of preventing, reducing, or eliminating at least one negative effect of oxidative damage, such as an oral disease, caused by a dental device in the mouth of a patient. Another embodiment relates to a method of preventing, reducing, or eliminating at least one negative effect of inflammation. The method may include applying topically to a soft oral tissue in the patient an oral antioxidant composition. The antioxidant composition may include between 0.0001% and 5.0% w/w or at least one antioxidant, wherein the at least one antioxidant includes a natural phytochemcial antioxidant, a flavonoid, an anthocyanidin, a dihydrochalcone, a phenylpropanoid, a chalcone, a curcuminoid, a tannin, a stilbenoid, a coumarin, a carotenoid, or a vitamin, and an orally pharmaceutically acceptable carrier. The pH of the oral antioxidant composition may be at least 5.0.

US Patent:

20150374652, Dec 31, 2015

Filed:

Sep 3, 2015

Appl. No.:

14/844219

Inventors:

- Dallas TX, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

International Classification:

A61K 31/192
A61K 31/045
A61K 9/00
A61K 31/05
A61K 9/08
A61K 31/12
A61K 31/047

Abstract:

One embodiment of the invention is directed to an oral antioxidant composition including between 0.0001% and 5.0% w/w antioxidant, wherein the antioxidant includes cinnamic acid derivative, tetrahydrocurcuminoids, or phloretin and an orally pharmaceutically acceptable carrier. The composition may have a pH of at least 5.0. According to still further embodiments, the composition may also include between 0.0001% and 5.0% w/w of one or two more additional antioxidants that include cinnamic acid derivative, tetrahydrcurcuminoids, phloretin, or a stilbene derivative. In more particular embodiments, the cinnamic acid derivative may include trans-ferulic acid, the tetrahydrocurcuminoids may include tetrahydrcurcuminoids CG™, or the stilbene derivative may include resveratrol. Other embodiments may relate to methods of treating or preventing an oral disease by applying topically an antioxidant composition as described above.

US Patent:

20140378547, Dec 25, 2014

Filed:

Sep 28, 2012

Appl. No.:

14/347724

Inventors:

- Dallas TX, US
Thomas Russell Moon - Dallas TX, US
Edward P. Allen - Dallas TX, US

International Classification:

A61K 31/192
A61K 9/00
A61K 31/12

US Classification:

514570

Abstract:

One embodiment of the invention is directed to a method of preventing, reducing, or eliminating at least one negative effect of oxidative damage, such as an oral disease, caused by a dental device in the mouth of a patient. Another embodiment relates to a method of preventing, reducing, or eliminating at least one negative effect of inflammation. The method may include applying topically to a soft oral tissue in the patient an oral antioxidant composition. The antioxidant composition may include between 0.0001% and 5.0% w/w or at least one antioxidant, wherein the at least one antioxidant includes a natural phytochemcial antioxidant, a flavonoid, an anthocyanidin, a dihydrochalcone, a phenylpropanoid, a chalcone, a curcuminoid, a tannin, a stilbenoid, a coumarin, a carotenoid, or a vitamin, and an orally pharmaceutically acceptable carrier. The pH of the oral antioxidant composition may be at least 5.0.