Thomas S Scanlan

US Patent:

6555582, Apr 29, 2003

Filed:

Aug 10, 1999

Appl. No.:

09/371592

Inventors:

Daniel M. Schwartz - San Francisco CA
John D. Baxter - San Francisco CA
Michele D. Jumper - SF CA
Thomas S. Scanlan - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31195

US Classification:

514568, 514913, 424427, 424428, 424429

Abstract:

The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.

US Patent:

6831093, Dec 14, 2004

Filed:

Jan 22, 2003

Appl. No.:

10/350260

Inventors:

Thomas S. Scanlan - San Francisco CA
Nilesh Shah - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31415

US Classification:

514406, 5483591

Abstract:

The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e. g. , obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

US Patent:

6979750, Dec 27, 2005

Filed:

Apr 18, 2003

Appl. No.:

10/418399

Inventors:

Thomas S. Scanlan - San Francisco CA, US
Matthew E. Hart - San Francisco CA, US
David K. Grandy - Portland OR, US
James R. Bunzow - Portland OR, US

Assignee:

The Regents of the University of California - Oakland CA
Oregon Health & Science University - Portland OR

International Classification:

C07C211/27
A61K031/35

US Classification:

564374, 514654

Abstract:

Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

US Patent:

7122579, Oct 17, 2006

Filed:

Feb 25, 2003

Appl. No.:

10/374681

Inventors:

Daniel M. Schwartz - San Francisco CA, US
John D. Baxter - San Francisco CA, US
Michele D. Jumper - San Francisco CA, US
Thomas S. Scanlan - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/195

US Classification:

514568

Abstract:

The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.

US Patent:

7196119, Mar 27, 2007

Filed:

Oct 20, 2004

Appl. No.:

10/970242

Inventors:

Thomas S. Scanlan - San Francisco CA, US
Martin J. Kelly - Portland OR, US
Jian Qiu - Portland OR, US
Sandra Tobias - San Francisco CA, US
Oline K. Ronnekleiv - Portland OR, US

Assignee:

The Regents of the University of California - Oakland CA
Oregon Health & Science University - Portland OR

International Classification:

A61K 31/167
C07C 233/01

US Classification:

514627, 564207, 564204, 564192, 564171, 564 95, 564 84, 560129, 514570, 514605

Abstract:

The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.

US Patent:

7302347, Nov 27, 2007

Filed:

Dec 10, 2002

Appl. No.:

10/317034

Inventors:

John D. Baxter - San Francisco CA, US
Thomas S. Scanlan - San Francisco CA, US
Robert J. Fetterick - Hillsborough CA, US
Sabine Borngraeber - San Francisco CA, US
Paul Webb - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/53
G06G 7/48

US Classification:

702 19, 702 20, 703 11, 707102, 435 71

Abstract:

This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.

US Patent:

7321065, Jan 22, 2008

Filed:

Apr 16, 2004

Appl. No.:

10/825881

Inventors:

Thomas S. Scanlan - San Francisco CA, US
Matthew E. Hart - San Francisco CA, US
David K. Grandy - Portland OR, US
James R. Bunzow - Portland OR, US
Motonori Miyakawa - South San Francisco CA, US
Edwin Saavedra Tan - San Francisco CA, US
Katherine L. Suchland - Portland OR, US

Assignee:

The Regents of the University of California - Oakland CA
Oregon Health & Science University - Portland OR

International Classification:

C07C 211/27
A61K 31/135

US Classification:

564374, 564316, 564336, 564347, 514648, 514649, 514651, 514654

Abstract:

Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

US Patent:

7339079, Mar 4, 2008

Filed:

Jun 17, 2005

Appl. No.:

11/155345

Inventors:

Thomas S. Scanlan - San Francisco CA, US
Matthew E. Hart - San Francisco CA, US
David K. Grandy - Portland OR, US
James R. Bunzow - Portland OR, US

Assignee:

The Regents of the University of California - Oakland CA
Oregon Health & Science University - Portland OR

International Classification:

C07C 211/27
A61K 31/135

US Classification:

564374, 564316, 564336, 564347, 514648, 514649, 514651, 514654

Abstract:

Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.