Timothy V Erickson

US Patent:

20180161433, Jun 14, 2018

Filed:

Jun 23, 2017

Appl. No.:

15/631843

Inventors:

Timothy Andrew Erickson - Beaverton OR, US

International Classification:

A61K 45/00
A61P 35/00
A61K 31/711
A61K 39/39
A61K 38/03
A61K 39/02
A61K 39/12
A61K 9/00

Abstract:

This invention describes novel immunogenic complexes, which are designed to trigger a robust host immune response against cancer cells by co-opting the immune system's natural ability to eliminate pathogen-infected host cells. The immunogenic complexes, referred to as microbial mimetics (MM) have unique physical and biochemical properties, which are designed to simulate a pathogenic infection of similar sized bacteria and viruses, permitting tumor-associated and tumor-specific peptide antigens to be presented to immune cells as microbial constituents. The MM are well-suited to mimic a systemic infection with microbe sized particles comprised largely of tumor antigens. Under this framework, tumor cells may be eliminated in the ensuing immune response.The microbial mimetics exhibit unique properties, including size tunability and contain antigenic cargo complexed to immune stimulatory molecules, which synergize to potentiate immune responses. The MM constitute a versatile platform for triggering immune responses against cells expressing epitopes contained within the complexed antigenic cargo.

US Patent:

20180113072, Apr 26, 2018

Filed:

Dec 19, 2017

Appl. No.:

15/847758

Inventors:

- Fort Collins CO, US
Timothy Erickson - Beaverton OR, US

International Classification:

G01N 21/41
G01N 33/18
G02B 6/122
G01M 11/00
G02B 6/12

Abstract:

A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

US Patent:

20170333542, Nov 23, 2017

Filed:

Jun 27, 2017

Appl. No.:

15/635069

Inventors:

Timothy Andrew Erickson - Beaverton OR, US

International Classification:

A61K 39/00

Abstract:

This invention describes novel immunogenic complexes, which are designed to trigger a robust host immune response against cancer cells by co-opting the immune system's natural ability to eliminate pathogen-infected host cells. The immunogenic complexes, referred to as microbial mimetics (MM) have unique physical and biochemical properties, which are designed to simulate a pathogenic infection of similar sized bacteria and viruses, permitting tumor-associated and tumor-specific peptide antigens to be presented to immune cells as microbial constituents. The MM are well-suited to mimic a systemic infection with microbe sized particles comprised largely of tumor antigens. Under this framework, tumor cells may be eliminated in the ensuing immune response.The MM exhibit unique properties, including size tunability and contain antigenic cargo complexed to immune stimulatory molecules, which synergize to potentiate immune responses. The MM constitute a versatile platform for triggering immune responses against cells expressing epitopes contained within the complexed antigenic cargo.

US Patent:

20170246274, Aug 31, 2017

Filed:

Feb 17, 2017

Appl. No.:

15/436525

Inventors:

Timothy Andrew Erickson - Beaverton OR, US

International Classification:

A61K 39/00

Abstract:

Disclosed are immunogenic compositions that include one or more polypeptides that, when administered to a subject with adjuvant, elicit an immune response against medullary thyroid cancer. Disclosed are methods of eliciting an immune response and/or treating cancer, such as medullary thyroid carcinoma or other thyroid carcinomas.

US Patent:

20170212044, Jul 27, 2017

Filed:

Apr 4, 2017

Appl. No.:

15/478982

Inventors:

- Fort Collins CO, US
Timothy Erickson - Beaverton OR, US

International Classification:

G01N 21/41
G01M 11/00
G02B 6/122
G01N 33/18

Abstract:

A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

US Patent:

20160116403, Apr 28, 2016

Filed:

May 8, 2014

Appl. No.:

14/889839

Inventors:

- Fort Collins CO, US
Timothy ERICKSON - Beaverton OR, US

International Classification:

G01N 21/41
G02B 6/42
G02B 6/12

Abstract:

A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

US Patent:

20150268162, Sep 24, 2015

Filed:

Oct 25, 2013

Appl. No.:

14/437039

Inventors:

- Port Collins CO, US
Timothy A. Erickson - Beaverton OR, US

Assignee:

Colorado State University Research Foundation - Fort Collins CO

International Classification:

G01N 21/41
H01L 31/105
G01N 21/77

Abstract:

An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal-semiconductor-metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator.