Timothy A Grieme from 320 Bayonne Ave, Green Oaks, IL 60044, age 53, Phone: 7733349537

Process For The Preparation Of 5-(Substituted)-10 Methoxy-2,2,4-Trimethyl-2,5-Dihydro-1H-Chromeno [3,4-F] Quinolines And Derivatives Thereof
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US Patent:

6673930, Jan 6, 2004
Filed:

Nov 7, 2002
Appl. No.:

10/289667
Inventors:

Yi-Yin Ku - Buffalo Grove IL 60089
Timothy A. Grieme - Chicago IL 60640
Padam N. Sharma - Gurnee IL 60031
Prasad S. Raje - Lindenhurst IL 60046
Howard E. Morton - Gurnee IL 60031
Mike A. Fitzgerald - Waukegan IL 60085
International Classification:

A61K 3144
US Classification:

546152, 546 62, 546 73, 546 95
Abstract:

The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.

Process For Preparing Amine-Substituted Benzofurans
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US Patent:

6822101, Nov 23, 2004
Filed:

Sep 5, 2003
Appl. No.:

10/654897
Inventors:

Yi-Yin Ku - Buffalo Grove IL
Yu-Ming Pu - Gurnee IL
Marlon D. Cowart - Round Lake Beach IL
Timothy A. Grieme - Chicago IL
Ashok K. Gupta - Gurnee IL
Daniel J. Plata - Wadsworth IL
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

C07D40706
US Classification:

548525, 546196
Abstract:

The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.

2-(6-{2-[(2R)-2-Methyl-1-Pyrrolidin-1-Yl]-Ethyl}-2-Naphthalen-2-Yl)-2H-Pyridazin-3-One Salts And Their Preparation
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US Patent:

7145005, Dec 5, 2006
Filed:

May 12, 2004
Appl. No.:

10/843917
Inventors:

Yi-Yin Ku - Buffalo Grove IL, US
Timothy A. Grieme - Chicago IL, US
Yu-Ming Pu - Gurnee IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

C07D 403/10
US Classification:

544238, 544239, 548579
Abstract:

The present invention relates to salts of 2-(6-{2-[(2R)-2-methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one, processes for their preparation, pharmaceutical compositions comprising such compounds, method of using them, and a process for preparing the active agent.

Fused Bicyclic-Substituted Amines As Histamine-3 Receptor Ligands
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US Patent:

7807697, Oct 5, 2010
Filed:

Jan 29, 2008
Appl. No.:

12/022041
Inventors:

Marlon D. Cowart - Round Lake Beach IL, US
Yi-Yin Ku - Buffalo Grove IL, US
Dilinie P. Fernando - Gurnee IL, US
Timothy A. Grieme - Chicago IL, US
Robert J. Altenbach - Chicago IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

A61K 31/4184
A61K 31/4439
A61K 31/4025
C07D 401/02
C07D 401/14
C07D 235/02
C07D 207/04
US Classification:

514336, 514387, 514422, 5462681, 5462734, 5483041, 5483061, 548518
Abstract:

Compounds of formula (I).

Process For Preparing Amine-Substituted Benzofurans
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US Patent:

20040054185, Mar 18, 2004
Filed:

Jul 2, 2003
Appl. No.:

10/613621
Inventors:

Marlon Cowart - Round Lake Beach IL, US
Yu-Ming Pu - Gurnee IL, US
Yi-Yin Ku - Buffalo Grove IL, US
Timothy Grieme - Chicago IL, US
Ashok Gupta - Gurnee IL, US
Daniel Plata - Wadsworth IL, US
Ramin Faghih - Lake Forest IL, US
Gregory Gfesser - Waukegan IL, US
International Classification:

C 07D 4 5/02
US Classification:

546/196000, 548/525000
Abstract:

The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile, and salts thereof. Compounds prepared by the processes of the invention have demonstrated activity as histamine-3 receptor ligands.

Fused Cycloalkyl Amides And Acids And Their Therapeutic Applications
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US Patent:

20040077617, Apr 22, 2004
Filed:

Oct 22, 2002
Appl. No.:

10/277308
Inventors:

Youssef Bennani - Shaker Heights OH, US
Sanjay Chemburkar - Gurnee IL, US
Michael Dart - Highland Park IL, US
Dilinie Fernando - Gurnee IL, US
Timothy Grieme - Chicago IL, US
International Classification:

A61K031/33
A61K031/397
A61K031/55
A61K031/54
A61K031/537
A61K031/495
A61K031/401
US Classification:

514/183000, 514/210170, 514/227500, 514/217110, 514/237500, 514/255010, 514/317000, 514/423000, 514/531000, 514/624000
Abstract:

The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.

Timothy A Grieme