Vinod A Singh

US Patent:

55854907, Dec 17, 1996

Filed:

Apr 5, 1993

Appl. No.:

8/030468

Inventors:

Andrew Thurkauf - Branford CT
Alan Hutchison - Madison CT
Vinod Singh - Branford CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D48704
C07D48710
C07D48720

US Classification:

544230

Abstract:

This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: n is 0, 1 or 2, and R. sub. 1, R. sub. 2, X, Y and W are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.

US Patent:

52161595, Jun 1, 1993

Filed:

Nov 27, 1991

Appl. No.:

7/800885

Inventors:

Andrew Thurkauf - Branford CT
Alan J. Hutchison - Madison CT
Vinod Singh - Branford CT

Assignee:

Neurogen Corporation - Branford CT

International Classification:

C07D47114

US Classification:

544250

Abstract:

The invention encompasses a compound of the formula ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein X, W, Y, R, and R2 are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.