Wei Tong

US Patent:

7435732, Oct 14, 2008

Filed:

Jun 7, 2005

Appl. No.:

11/146730

Inventors:

Wei Tong - Suffern NY, US
Abdolsamad Tadayon - Kirkland, CA
Peter John Larkin - Stratford CT, US
Lalitha Krishnan - Suffern NY, US
Subodh S. Deshmukh - White Plains NY, US
Jean Marie Akin - Cross River NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 279/12
A61K 31/54

US Classification:

5142275, 544 584

Abstract:

This invention relates to crystalline polymorphs of (3S)-N-hydroxy4-({4-[(4-hydroxy-2-butynyl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholine carboxamide, and preparation and uses thereof.

US Patent:

7507739, Mar 24, 2009

Filed:

Sep 24, 2004

Appl. No.:

10/950543

Inventors:

Nan Zhang - Bayside NY, US
Thai Nguyen - Fair Lawn NJ, US
Yanzhong Wu - Bronx NY, US
Wei Tong - Suffern NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 487/04
A61K 31/519
A61P 35/04

US Classification:

5142593, 544263

Abstract:

This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

US Patent:

7553843, Jun 30, 2009

Filed:

Dec 6, 2006

Appl. No.:

11/634774

Inventors:

Subodh S. Deshmukh - White Plains NY, US
Clifford William Coughlin - Plattsburgh NY, US
Chunhao Zhang - La Salle, CA
Adam P. Michaud - Lawrenceville NJ, US
Lynn M. Phelan - Lake Hiawatha NJ, US
Wei Tong - Suffern NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 498/12
A61K 31/453
A61P 35/00

US Classification:

514291, 540456

Abstract:

The present invention provides purified crystalline CCI-779 and processes for preparing the same.

US Patent:

8641948, Feb 4, 2014

Filed:

Mar 19, 2012

Appl. No.:

13/423329

Inventors:

Jennifer Snyder - Morris Plains NJ, US
Wei Quin Tong - Basking Ridge NJ, US
Sudha Vippagunta - Morris Plains NJ, US

Assignee:

Novartis AG - Basel

International Classification:

B29C 47/00
B29C 67/24

US Classification:

264211, 2641761, 26421121, 424465

Abstract:

A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.

US Patent:

20080249303, Oct 9, 2008

Filed:

Mar 28, 2008

Appl. No.:

12/057465

Inventors:

Wei TONG - Suffern NY, US
Carl E. LONGFELLOW - Warwick NY, US

Assignee:

WYETH - Madison NJ

International Classification:

C07D 401/12
G01N 23/20

US Classification:

540602, 378 71

Abstract:

Methods are disclosed for separating and detecting bazedoxifene acetate from pharmaceutical compositions containing a mixture of bazedoxifene acetate and one or more other components that produce X-Ray diffraction patterns having interfering peaks at or near the characteristic peaks for bazedoxifene acetate.