Wei X Xia

US Patent:

57706182, Jun 23, 1998

Filed:

Nov 13, 1996

Appl. No.:

8/748356

Inventors:

Charanjit R. Behl - Hauppauge NY
Jorge C. deMeireles - Syosset NY
Vincent D. Romeo - Massapequa Park NY
Anthony P. Sileno - Brookhaven Hamlet NY
Harish K. Pimplaskar - Lindenhurst NY
Wei J. Xia - Melville NY

Assignee:

Nastech Pharmaceutical Company, Inc. - Hauppauge NY

International Classification:

A61K 3140

US Classification:

514408

Abstract:

A method is disclosed for increasing the solubility of clemastine through the use of organic acid or its salts as a solubilizing agent. Particularly useful as solubilizing agents are salts of carboxylic acids, such as fumarate, maleate and citrate. Pharmaceutical compositions containing clemastine, and organic acids or its salts as solubilizing agents, are also disclosed.

US Patent:

58744509, Feb 23, 1999

Filed:

Sep 29, 1997

Appl. No.:

8/939279

Inventors:

Charanjit R. Behl - Hauppauge NY
Jorge C. DeMeireles - Syosset NY
Harish K. Pimplaskar - Lindenhurst NY
Vincent D. Romeo - Massapequa Park NY
Anthony P. Sileno - Brookhaven Hamlet NY
Wei J. Xia - Melville NY

Assignee:

Nastech Pharmaceutical Company, Inc. - Hauppauge NY

International Classification:

A61K 908
A61K 31435

US Classification:

514357

Abstract:

Intranasal dosage units for promoting sleep in a mammal are disclosed. The dosage units are in the form of an aqueous buffered solution having a pH greater than 7. 0, a sleep-promoting amount of Doxylamine, and an effective amount of an anionic surfactant. The anionic surfactant amount is an amount effective to provide a peak plasma concentration of Doxylamine to be reached within 30 minutes of administering the dosage unit to the nasal mucosa of a mammal. The dosage units are particularly suitable for administration to humans.