Wei Xu

US Patent:

6444680, Sep 3, 2002

Filed:

Nov 29, 2001

Appl. No.:

09/998416

Inventors:

Guy R. Humphrey - Hillsborough NJ
Marjorie See Waters - Cranbury NJ
Wei Xu - North Wales PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40114

US Classification:

514256, 544333

Abstract:

Amine salts of -( -methyl-pyrimidin- -yl)- -( -tetrahydro-[ ]-naphthyridin- -yl)-nonanoic acid are potent antagonists of the integrin v receptor and are useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salts as well as pharmaceutical compositions containing the salts and methods of using the salts. Also disclosed are (R)- and (S)-( -methylpyrimidin- -yl)- -( -tetrahydro-[ ]naphthyridin- -yl)-nonanoic acid in the form of a zwitterion trihydrate.

US Patent:

6750220, Jun 15, 2004

Filed:

Jun 18, 2002

Appl. No.:

10/174016

Inventors:

Guy R. Humphrey - Hillsborough NJ
Wei Xu - North Wales PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40114

US Classification:

514256, 544333

Abstract:

The tris(hydroxymethyl)aminomethane (âTRISâ) salt of 3-(pyrimidin-5-yl)-9-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-nonanoic acid is a potent antagonist of the integrin v3 receptor and is useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salt as well as pharmaceutical compositions containing the salt and methods of using the salt.

US Patent:

7816353, Oct 19, 2010

Filed:

Oct 22, 2004

Appl. No.:

10/576653

Inventors:

Wei Cheng - Edison NJ, US
Erick Wang Co - San Diego CA, US
Moon Hwan Kim - Palo Alto CA, US
Rhett Ronald Klein - Chicago IL, US
Donna T. Le - San Jose CA, US
Amy Lew Tsuhako - Milpitas CA, US
John M. Nuss - Danville CA, US
Wei Xu - Danville CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C07D 239/38
C07D 413/04
C07D 413/12
C07D 403/12
A61K 31/505
A61K 31/5355
A61K 31/506
A61K 31/496
A61K 31/501
C07D 211/88
C07D 251/38
C07D 487/04
C07D 491/048
A61K 31/44
A61K 31/53
A61K 31/519
A61K 31/4355

US Classification:

5142358, 514272, 51425214, 514344, 514245, 5142621, 514302, 544321, 544122, 544238, 544295, 544262, 546288, 546115

Abstract:

Compounds of formula III:.

US Patent:

20110021525, Jan 27, 2011

Filed:

Jul 20, 2010

Appl. No.:

12/839925

Inventors:

Wei Cheng - Edison NJ, US
Erick Wang Co - San Diego CA, US
Moon Hwan Kim - Palo Alto CA, US
Rhett Ronald Klein - Chicago IL, US
Donna T. Le - San Jose CA, US
Amy Lew Tsuhako - Milpitas CA, US
John M. Nuss - Danville CA, US
Wei Xu - Danville CA, US

Assignee:

EXELIXIS, INC. - South San Francisco CA

International Classification:

A61K 31/5377
A61K 31/505
A61P 35/00
A61P 37/06
A61P 19/02
A61P 17/06
A61P 9/10
A61P 3/10
A61P 3/04
A61P 29/00
A61P 27/02
A61P 35/04
C12N 5/00
A61K 31/506

US Classification:

5142358, 514272, 435375, 51425214

Abstract:

The invention provides compounds and methods for inhibition of kinases, more specifically p70S6 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

US Patent:

20220177331, Jun 9, 2022

Filed:

Feb 25, 2022

Appl. No.:

17/681581

Inventors:

- Hoboken NJ, US
Ronald Besser - New Providence NJ, US
Jian Xu - West Lafayette IN, US
Wei Xu - Farmingdale NY, US
Brendan Englot - New York NY, US
Chang-Hwan Choi - Tenafly NJ, US

Assignee:

THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY - Hoboken NJ

International Classification:

C02F 1/40
C02F 1/28

Abstract:

Smart membranes are integrated into a small, unmanned surface vessel to enable the efficient, automated cleanup of oil spills. Such a vessel has the potential to provide a low-cost, modular solution for day-to-day oil-spill cleanup operations, especially in confined aquatic areas (e.g., under piers or in the small spaces between marine vessels and piers). The membranes are provided on the surface of a conveyor belt that circulates the membranes through the surrounding body of water for oil collection, as well as through an internal reduction chamber of the vessel for oil release. The smart membranes are adapted to attract and repel oil in response to low-voltage commands applied across the conveyor belt, using a process that is repeatable for a number of cycles, offering high efficiency and long durability. Segments of the conveyor belt can be electrically isolated from one another to allow disparate electrical potentials to be imposed thereon.

US Patent:

20200082406, Mar 12, 2020

Filed:

Sep 6, 2018

Appl. No.:

16/124004

Inventors:

- Purchase NY, US
Wei Xu - Millwood NY, US

International Classification:

G06Q 20/40
G06Q 20/08

Abstract:

An electronic payment card processing system and method includes at least one computing device in communication with a multi-party payment processing system and network for processing payment card transactions. The computing device receives transaction data for a plurality of payment card transactions identifies foreign exchange transactions based on the received transaction data, and applies a chargeback loss mitigation rule to filter a chargeback request for a disputed transaction charge that relates to an identified foreign exchange transaction, thereby preventing an unnecessary chargeback for the foreign exchange transaction.

US Patent:

20190130409, May 2, 2019

Filed:

Oct 26, 2017

Appl. No.:

15/794538

Inventors:

- Purchase NY, US
Wei Xu - Millwood NY, US

International Classification:

G06Q 20/40
G06Q 20/10
G06Q 20/34

Abstract:

A message is generated to initiate an ACH (automated clearing house) transaction to benefit a recipient account associated with a recipient token. The message includes the recipient token. After the message is transmitted, an authentication message is received. The authentication message indicates authentication of the recipient token. The ACH transaction is implemented in response to receiving the authentication message.

US Patent:

20180112069, Apr 26, 2018

Filed:

Mar 29, 2016

Appl. No.:

15/562638

Inventors:

- Baltimore MD, US
Wei XU - Basking Ridge NJ, US
Linfeng GOU - Chesterbrook PA, US
Robert WIACEK - Silver Spring MD, US
Selina MONICKAM - Takoma Park MD, US
Brian WEHRENBERG - Baltimore MD, US
Amy STABELL - Baltimore MD, US
Maneesh BAHADUR - Midland MI, US
Serpil Gonen WILLIAMS - Lanham MD, US

International Classification:

C08K 9/06
C08L 83/04
H01L 33/56
H01L 33/58

Abstract:

At least partially capped nanocrystals and nanocomposites containing the nanocrystals are described herein along with products, uses and methods of making.