Wei H Xu

US Patent:

6350746, Feb 26, 2002

Filed:

Dec 8, 1999

Appl. No.:

09/457457

Inventors:

Brad O. Buckman - Oakland CA
David D. Davey - El Sobrante CA
William J. Guilford - San Leandro CA
Michael M. Morrissey - Danville CA
Howard P. Ng - El Sobrante CA
Gary B. Phillips - Pleasant Hill CA
Shung C. Wu - El Cerrito CA
Wei Xu - Richmond CA

Assignee:

Berlex Laboratories, Inc. - Richmond CA

International Classification:

C07D40112

US Classification:

5142315, 51425213, 514318, 514335, 514336, 544111, 544194, 544360, 546296, 546298

Abstract:

This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

US Patent:

6350761, Feb 26, 2002

Filed:

Jul 24, 2000

Appl. No.:

09/624519

Inventors:

William J. Guilford - Belmont CA
Steven T. Sakata - San Diego CA
Kenneth J. Shaw - San Rafael CA
Shung Wu - Princeton NJ
Wei Xu - Danville CA
Zuchun Zhao - Richmond CA

Assignee:

Berlex Laboratories, Inc. - Richmond CA

International Classification:

A61K 31445

US Classification:

514327, 514329, 514424, 514426, 514432, 514448, 546216, 546223, 548530, 548544, 548559, 549 28, 549 65, 549 68, 549 69, 549416, 549419, 549475, 549480

Abstract:

This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R , R , R , R , R and R are defined herein. These compounds are useful as anti-coagulants.

US Patent:

6465459, Oct 15, 2002

Filed:

Aug 8, 2001

Appl. No.:

09/924412

Inventors:

Brad O. Buckman - Oakland CA
David D. Davey - El Sobrante CA
William J. Guilford - San Leandro CA
Michael M. Morrissey - Danville CA
Howard P. Ng - El Sobrante CA
Gary B. Phillips - Pleasant Hill CA
Shung C. Wu - El Cerrito CA
Wei Xu - Richmond CA

Assignee:

Berlex Laboratories, Inc. - Richmond CA

International Classification:

A61K 3153

US Classification:

514241, 544180, 544219

Abstract:

This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

US Patent:

6479485, Nov 12, 2002

Filed:

Aug 7, 2001

Appl. No.:

09/924413

Inventors:

Brad O. Buckman - Oakland CA
David D. Davey - El Sobrante CA
William J. Guilford - San Leandro CA
Michael M. Morrissey - Danville CA
Howard P. Ng - El Sobrante CA
Gary B. Phillips - Pleasant Hill CA
Shung C. Wu - El Cerrito CA
Wei Xu - Richmond CA

Assignee:

Berlex Laboratories, Inc. - Richmond CA

International Classification:

A61K 31534

US Classification:

5142312, 548517, 548541, 548543, 546186, 546192, 546194, 546207, 5142315, 51425211, 51425213, 51425501, 514317, 514422, 514424, 514427, 544359, 544360, 544372, 544382, 544383, 544403

Abstract:

This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

US Patent:

6686364, Feb 3, 2004

Filed:

Aug 7, 2001

Appl. No.:

09/924893

Inventors:

Brad O. Buckman - Oakland CA
David D. Davey - El Sobrante CA
William J. Guilford - San Leandro CA
Michael M. Morrissey - Danville CA
Howard P. Ng - El Sobrante CA
Gary B. Phillips - Pleasant Hill CA
Shung C. Wu - El Cerrito CA
Wei Xu - Richmond CA

Assignee:

Berlex Laboratories, Inc. - Richmond CA

International Classification:

A61K 314965

US Classification:

51425506, 514275, 544297, 544298, 544405

Abstract:

This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

US Patent:

7440615, Oct 21, 2008

Filed:

Oct 26, 2006

Appl. No.:

11/553043

Inventors:

Yihong Gong - Saratoga CA, US
Mei Han - Cupertino CA, US
Wei Xu - Princeton CA, US

Assignee:

NEC Laboratories America, Inc. - Princeton NJ

International Classification:

G06K 9/34

US Classification:

382173

Abstract:

A fully automatic, computationally efficient segmentation method of video employing sequential clustering of sparse image features. Both edge and corner features of a video scene are employed to capture an outline of foreground objects and the feature clustering is built on motion models which work on any type of object and moving/static camera in which two motion layers are assumed due to camera and/or foreground and the depth difference between the foreground and background. Sequential linear regression is applied to the sequences and the instantaneous replacements of image features in order to compute affine motion parameters for foreground and background layers and consider temporal smoothness simultaneously. The Foreground layer is then extracted based upon sparse feature clustering which is time efficient and refined incrementally using Kalman filtering.

US Patent:

7498358, Mar 3, 2009

Filed:

Dec 13, 2002

Appl. No.:

10/498338

Inventors:

S. David Brown - San Carlos CA, US
Erick Wang Co - Redwood City CA, US
Vasu Jammalamadaka - Pleasonton CA, US
Rickard George Khoury - Redwood City CA, US
Moon Hwan Kim - Palo Alto CA, US
Donna T. Le - San Jose CA, US
Amy Lew Tsuhako - Milpitas CA, US
Morrison B. Mac - San Francisco CA, US
John M. Nuss - Danville CA, US
Michael P. Prisbylla - Pleasant Hill CA, US
Wei Xu - Danville CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C07C 311/19
C07C 311/29
C07C 259/06
C07C 259/08
C07D 213/32
C07D 213/68
A61K 31/16
A61K 31/44
A61P 19/02
A61P 35/00
A61P 9/10

US Classification:

514507, 562621, 562623, 564 80, 560 12, 5462721, 5462834, 514351, 514357, 514518, 514562

Abstract:

The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.

US Patent:

7626031, Dec 1, 2009

Filed:

Nov 14, 2003

Appl. No.:

10/533555

Inventors:

Wei Xu - Danville CA, US
Erick Wang Co - Redwood City CA, US
John M. Nuss - Danville CA, US
Moon Hwan Kim - Palo Alto CA, US
Rhett Ronald Klein - San Francisco CA, US
Donna Tra Le - San Jose CA, US
Amy Lew Tsuhako - Milpitas CA, US
Jason Jevious Parks - Sacramento CA, US
Zhaoyang Wen - San Francisco CA, US
Wei Cheng - San Jose CA, US

Assignee:

Symphony Evolution, Inc. - Rockville MD

International Classification:

C07D 401/00
A61K 31/445

US Classification:

546196, 514320

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.