Xiaojun Xia

US Patent:

20130195963, Aug 1, 2013

Filed:

Dec 7, 2012

Appl. No.:

13/708888

Inventors:

The Methodist Hospital Research Institute - Houston TX, US
Ismail Mustafa Meraz - Pearland TX, US
Jianhua Gu - Houston TX, US
Xiaojun Xia - Houston TX, US
Haifa Shen - Bellaire TX, US
Tong Sun - Houston TX, US
Mauro Ferrari - Houston TX, US

Assignee:

The Methodist Hospital Research Institute - Houston TX

International Classification:

A61K 9/14
A61K 39/00

US Classification:

424450, 424490, 4242771

Abstract:

Disclosed are mesoporous silicon multi-stage vehicles that comprise liposomal-based second-stage particles, as well as pharmaceutical compositions and formulations including such vectors for use in a variety of diagnostic and therapeutic indications. In particular embodiments, MSV comprising ligand decorated second-stage particles are provided for therapeutic methods including, for example, treatment of mammalian cancers, including those of the human breast.

US Patent:

20180117176, May 3, 2018

Filed:

Dec 6, 2017

Appl. No.:

15/832771

Inventors:

- Houston TX, US
Xiaojun XIA - Pearland TX, US
Mauro FERRARI - Houston TX, US

International Classification:

A61K 47/69
A61K 39/39
A61K 39/00
A61K 39/12
B82Y 5/00
C12N 5/0783
A61K 9/51
C12N 15/113
A61P 35/04

Abstract:

Porous silicon (pSi) microparticles (PSM) are disclosed, which provide an important advance in the area of cancer immunotherapeutics and molecular nanomedicine. In particular, potent PSM-based adjuvants are disclosed for dendritic cell-based vaccines compositions, and methods for their use in a variety of cancer immunotherapies. The PSM of the present invention are also useful in developing other types of vaccines, including those not necessarily related to the treatment of cancers, such as vaccines for the treatment of acne, Alzheimer's disease, asthma, atherosclerosis, autoimmune disorders, autoinflammatory disease, celiac disease, colitis, Crohn's disease, diabetes, glomerulonephritis, infectious diseases, inflammatory bowel disease, irritable bowel syndrome, ischemia, Lupus, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, West Nile virus, and related illnesses.