Xiaoling Lu

US Patent:

20200253964, Aug 13, 2020

Filed:

Apr 27, 2020

Appl. No.:

16/859357

Inventors:

- Summit NJ, US
Gordon L. Bray - San Francisco CA, US
James Carmichael - Nottingham, GB
Soraya Carrancio - San Diego CA, US
Brian E. Cathers - San Diego CA, US
Matthew D. Correa - San Diego CA, US
Joshua Hansen - La Jolla CA, US
Courtney G. Havens - San Diego CA, US
Timothy S. Kercher - Longmont CO, US
Xiaoling Lu - Whippany NJ, US
Hon-Wah Man - Princeton NJ, US
Mark A. Nagy - Encinitas CA, US
Rama K. Narla - San Diego CA, US
Joseph R. Piccotti - Encinitas CA, US
Daniel W. Pierce - Belmont CA, US
Brandon W. Whitefield - San Diego CA, US
Lilly L. Wong - Solana Beach CA, US
Nanfei Zou - Fanwood NJ, US

International Classification:

A61K 31/496
A61P 35/00
C07D 401/04
A61K 38/05
A61K 31/573
A61P 35/02

Abstract:

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

US Patent:

20200002316, Jan 2, 2020

Filed:

Sep 13, 2019

Appl. No.:

16/570191

Inventors:

- Summit NJ, US
Timothy D. FITZPATRICK - Kirkland WA, US
Anthony FRANK - Easton PA, US
Ying LI - Millburn NJ, US
Xiaoling LU - Whippany NJ, US
Marie G. BEAUCHAMPS - Randolph NJ, US
Antonio C. FERRETTI - Summit NJ, US

International Classification:

C07D 403/10
A61P 35/00

Abstract:

Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

US Patent:

20190282567, Sep 19, 2019

Filed:

Jun 3, 2019

Appl. No.:

16/430189

Inventors:

- Summit NJ, US
Gordon L. Bray - San Francisco CA, US
James Carmichael - Nottingham, GB
Soraya Carrancio - San Diego CA, US
Brian E. Cathers - San Diego CA, US
Matthew D. Correa - San Diego CA, US
Joshua Hansen - La Jolla CA, US
Courtney G. Havens - San Diego CA, US
Timothy S. Kercher - San Diego CA, US
Xiaoling Lu - Whippany NJ, US
Hon-Wah Man - Princeton NJ, US
Mark A. Nagy - Encinitas CA, US
Rama K. Narla - San Diego CA, US
Joseph R. Piccotti - Encinitas CA, US
Daniel W. Pierce - Belmont CA, US
Brandon W. Whitefield - San Diego CA, US
Lilly L. Wong - Solana Beach CA, US
Nanfei Zou - Fanwood NJ, US

International Classification:

A61K 31/496
C07D 401/04
A61K 31/573
A61P 35/02
A61K 38/05
A61P 35/00

Abstract:

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

US Patent:

20190100512, Apr 4, 2019

Filed:

Dec 15, 2015

Appl. No.:

15/537331

Inventors:

- Summit NJ, US
Timothy D. FITZPATRICK - Kirkland WA, US
Anthony FRANK - Easton PA, US
Ying LI - Millburn NJ, US
Xiaoling LU - Whippany NJ, US
Marie G. BEAUCHAMPS - Randolph NJ, US
Antonio C. FERRETTI - Summit NJ, US

Assignee:

Celgene Corporation - Summit NJ

International Classification:

C07D 403/10
A61P 35/00

Abstract:

Provided herein are compositions including the crystalline forms of (1E, 4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b] azepine-4-carboxamide (“Compound A”), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer.

US Patent:

20190100522, Apr 4, 2019

Filed:

Oct 3, 2018

Appl. No.:

16/150345

Inventors:

- Summit NJ, US
Maryll Elaine GEHERTY - Pennington NJ, US
Matthew Michael KREILEIN - Hillsborough NJ, US
Xiaoling LU - Whippany NJ, US
Nanfei ZOU - Fanwood NJ, US

International Classification:

C07D 473/32
C07D 407/12

Abstract:

Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide, alternatively named (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide, or a salt, solvate, hydrate, or isotopologue thereof.

US Patent:

20190008852, Jan 10, 2019

Filed:

Jul 9, 2018

Appl. No.:

16/030695

Inventors:

- Summit NJ, US
Gordon L. Bray - San Francisco CA, US
James Carmichael - Nottingham, GB
Soraya Carrancio - San Diego CA, US
Brian E. Cathers - San Diego CA, US
Matthew D. Correa - San Diego CA, US
Joshua Hansen - La Jolla CA, US
Courtney G. Havens - San Diego CA, US
Timothy S. Kercher - San Diego CA, US
Xiaoling Lu - Whippany NJ, US
Hon-Wah Man - Princeton NJ, US
Mark A. Nagy - Encinitas CA, US
Rama K. Narla - San Diego CA, US
Joseph R. Piccotti - Encinitas CA, US
Daniel W. Pierce - Belmont CA, US
Brandon W. Whitefield - San Diego CA, US
Lilly L. Wong - Solana Beach CA, US
Nanfei Zou - Fanwood NJ, US

International Classification:

A61K 31/496
A61P 35/02

Abstract:

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

US Patent:

20180362529, Dec 20, 2018

Filed:

Jul 5, 2018

Appl. No.:

16/027503

Inventors:

- San Diego CA, US
Paul F. Fernandez - Roseland NJ, US
Tracy L. Gaebele - Green Brook NJ, US
Lianfeng Huang - Basking Ridge NJ, US
Matthew J. Jackson - Watchung NJ, US
Matthew M. Kreilein - Hillsborough NJ, US
Xiaoling Lu - Whippany NJ, US
Wenju Wu - Warren NJ, US
Jean Xu - Warren NJ, US

International Classification:

C07D 473/32

Abstract:

Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.

US Patent:

20170283418, Oct 5, 2017

Filed:

Mar 31, 2017

Appl. No.:

15/475836

Inventors:

- San Diego CA, US
Paul F. Fernandez - Roseland NJ, US
Tracy L. Gaebele - Green Brook NJ, US
Lianfeng Huang - Basking Ridge NJ, US
Matthew J. Jackson - Watchung NJ, US
Matthew M. Kreilein - Hillsborough NJ, US
Xiaoling Lu - Whippany NJ, US
Wenju Wu - Warren NJ, US
Jean Xu - Warren NJ, US

International Classification:

C07D 473/32

Abstract:

Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4, 6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.