Xiaoling Lu

US Patent:

20190100522, Apr 4, 2019

Filed:

Oct 3, 2018

Appl. No.:

16/150345

Inventors:

- Summit NJ, US
Maryll Elaine GEHERTY - Pennington NJ, US
Matthew Michael KREILEIN - Hillsborough NJ, US
Xiaoling LU - Whippany NJ, US
Nanfei ZOU - Fanwood NJ, US

International Classification:

C07D 473/32
C07D 407/12

Abstract:

Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide, alternatively named (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide, or a salt, solvate, hydrate, or isotopologue thereof.