Xiaoming M Liu

US Patent:

20030204861, Oct 30, 2003

Filed:

Apr 30, 2002

Appl. No.:

10/136723

Inventors:

Madaiah Puttaraju - Germantown MD, US
Lloyd Mitchell - Bethesda MD, US
John Engelhardt - Iowa City IA, US
Xiaoming Liu - Iowa City IA, US

International Classification:

A01K067/027

US Classification:

800/018000

Abstract:

The present invention relates to development of an animal model system for in vivo testing of spliceosome-mediated RNA trans-splicing reactions. The present invention provides transgenic animals, and methods for generating such animals, that have been genetically engineered to expresses a target precursor messenger RNA molecule (target pre-mRNA) that serves as a substrate for a trans-splicing reaction. Specifically, the transgenic animals contain at least one transgene capable of expressing a target pre-mRNA molecule. The invention provides methods, based on utilization of the transgenic animals, for assessing the specificity and efficiency of a pre-trans-splicing molecule (PTM) designed to interact with a target pre-mRNA and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule. The present invention further relates to the transgenic expression of PTM molecules in animals to determine gene function, i.e, functional genetics. The present invention is based on the successful generation of a transgenic animal expressing a target pre-mRNA and, moreover, the use of that animal to detect accurate in vivo trans-splicing reactions in the presence of a PTM.

US Patent:

20090053655, Feb 26, 2009

Filed:

Mar 21, 2008

Appl. No.:

12/053058

Inventors:

Xuegong Deng - Piscataway NJ, US
Jian Jim Wang - Orefield PA, US
Lei Chen - Clarksburg MD, US
Anguel N. Nikolov - Los Angeles CA, US
Nada O'Brien - Santa Rosa CA, US
Xiaoming Liu - Orefield PA, US

Assignee:

NANOOPTO CORPORATION - Somerset NJ

International Classification:

G03F 7/20
C23F 1/02

US Classification:

430321, 216 24

Abstract:

In general, in a first aspect, the invention features a method that includes forming a first layer comprising a first material over a surface of a second layer, wherein forming the first layer includes sequentially forming a plurality of monolayers of the second material over the surface of the second layer, the second layer comprises a plurality of rows of a second material extending along a first direction and spaced from one another in a second direction orthogonal to the first direction, and the first layer conforms to the surface of the second layer. The method further includes removing portions of the first layer to produce a plurality of rows of the first material extending along the first direction and spaced from one another in the second direction and removing portions of a third layer comprising a third material, where the portions correspond to intervals between the second plurality of rows so that removing the portions forms a plurality of rows of the third material extending along the first direction and spaced apart from one another. The first and second materials are different.

US Patent:

20130148866, Jun 13, 2013

Filed:

Feb 6, 2013

Appl. No.:

13/760670

Inventors:

Lockheed Martin Corporation - Bethesda MD, US
Frederick W. Wheeler - Niskayuna NY, US
Peter H. Tu - Niskayuna NY, US
Xiaoming Liu - Schenectady NY, US

Assignee:

Lockheed Martin Corporation - Bethesda MD

International Classification:

G06K 9/62

US Classification:

382115

Abstract:

A biometric sample training device, a biometric sample quality assessment device, a biometric fusion recognition device, an integrated biometric fusion recognition system and example processes in which each may be used are described. Wavelets and a boosted classifier are used to assess the quality of biometric samples, such as facial images. The described biometric sample quality assessment approach provides accurate and reliable quality assessment values that are robust to various degradation factors, e.g., such as pose, illumination, and lighting in facial image biometric samples. The quality assessment values allow biometric samples of different sample types to be combined to support complex recognition techniques used by, for example, biometric fusion devices, resulting in improved accuracy and robustness in both biometric authentication and biometric recognition.

US Patent:

6547648, Apr 15, 2003

Filed:

Oct 13, 2000

Appl. No.:

09/687548

Inventors:

Zhenqi Zhu - Holmdel NJ
Xiaoming Liu - Jersey City NJ

Assignee:

Trustees of Stevens Institute of Technology - Graduate School and Research Services - Hoboken NJ

International Classification:

B24B 100

US Classification:

451 49, 451 56, 451 72, 451443

Abstract:

This invention is a process and device for high speed electrolytic in-process dressing (HELID). The device of the present invention may be provided as an add on to an existing grinding machine or may be integrated into a grinding machine as a subsystem. Grinding machines which are subject to the present invention include, but are not limited to, surface, cylindrical, centerless and double-disk grinding machines.