Yang Tan Lu

US Patent:

20220203372, Jun 30, 2022

Filed:

Dec 28, 2021

Appl. No.:

17/563415

Inventors:

- Cambridge MA, US
Steven Nagle - Cambridge MA, US
Christopher Werley - Cambridge MA, US
Yang Lu - Cambridge MA, US
Adam Barnett - Cambridge MA, US
Owen McManus - Belmont MA, US
Graham T. Dempsey - Cambridge MA, US

International Classification:

B01L 9/00
G01N 21/25
G01N 35/02
G01N 33/50
G01N 35/00
B01L 3/00

Abstract:

The present invention includes multi-well plate readers, and methods of their use. The multi-well plate readers can transmit stimulation light to, and detect emission light from, individual wells of a multi-well plate, simultaneously.

US Patent:

20220205914, Jun 30, 2022

Filed:

Dec 28, 2021

Appl. No.:

17/563385

Inventors:

- Cambridge MA, US
Steven Nagle - Cambridge MA, US
Christopher Werley - Cambridge MA, US
Yang Lu - Cambridge MA, US
Adam Barnett - Cambridge MA, US
Owen McManus - Belmont MA, US
Graham T. Dempsey - Cambridge MA, US

International Classification:

G01N 21/64

Abstract:

The present invention includes multi-well plate readers, and methods of their use. The multi-well plate readers can transmit stimulation light to, and detect emission light from, individual wells of a multi-well plate at a plurality of distinct wavelengths.

US Patent:

20220205979, Jun 30, 2022

Filed:

Dec 28, 2021

Appl. No.:

17/563400

Inventors:

- Cambridge MA, US
Steven Nagle - Cambridge MA, US
Christopher Werley - Cambridge MA, US
Yang Lu - Cambridge MA, US
Adam Barnett - Cambridge MA, US
Owen McManus - Belmont MA, US
Graham T. Dempsey - Cambridge MA, US

International Classification:

G01N 33/50
G01N 33/487
G01N 33/542

Abstract:

The present invention includes methods and systems for optical assays, such as optogenetic assays, of biological activity in which an optical reference signal is used to normalize an optical test signal.

US Patent:

20220206280, Jun 30, 2022

Filed:

Dec 28, 2021

Appl. No.:

17/563434

Inventors:

- Cambridge MA, US
Yang Lu - Cambridge MA, US
Arvind Mohan - Cambridge MA, US
Pin Liu - Cambridge MA, US
Graham T. Dempsey - Cambridge MA, US
Nate Bremmer - Cambridge MA, US
William Amar - Cambridge MA, US
Hongkang Zhang - Wellesley MA, US

International Classification:

G02B 21/26
G01N 21/03
G01N 21/64
G02B 21/06
G02B 27/10
G02B 27/14
G02B 21/16
G02B 21/36
G02B 26/08

Abstract:

The inventions provide microscopes for imaging samples within wells of multi-well plates. Microscopes of the disclosure include a beam homogenizer system that shapes a beam from a light source into a shape specific to the bottom of a well of a multi-well plate. In particular, microscopes of the disclosure can illuminate wells for imaging by passing light through a prism that is beneath the sample. The light enters the prism from the side and as refracted into the well at a steep angle such that the light only illuminates about a bottom ten microns of the well. The beam homogenizer shapes the light from the light source so that, instead of hitting the prism as a spot with an irregular shape, the light enters the prism in a substantially rectangular pattern with homogeneous optical power level over the pattern.

US Patent:

20230003647, Jan 5, 2023

Filed:

Jun 30, 2022

Appl. No.:

17/854425

Inventors:

- Cambridge MA, US
Yang Lu - Cambridge MA, US
Benjamin Harwood - Cambridge MA, US
Hongkang Zhang - Wellesley MA, US
Christopher Werley - Cambridge MA, US
Owen McManus - Belmont MA, US
Graham T. Dempsey - Sudbury MA, US

International Classification:

G01N 21/64
G01N 21/01
B01L 9/00

Abstract:

The invention provides a multi-well plate reader for providing simultaneous transmission of stimulation light to, and detection of emission light from, individual wells of a multi-well plate at a plurality of distinct wavelengths.

US Patent:

20180101589, Apr 12, 2018

Filed:

Sep 14, 2017

Appl. No.:

15/704414

Inventors:

- Bedford MA, US
Walter Weiss - Chelmsford MA, US
Yang Lu - Woburn MA, US
Rui Shen - Burlington MA, US
Manju James - Lexington MA, US

International Classification:

G06F 17/30

Abstract:

Database replication is performed by tracking sequence numbers associated with binary change logs. At a producer cluster, a binary change log is generated based on a write transaction made to a database partition in the producer cluster. Included with the binary change log is a sequence number corresponding to the write transaction. The binary change log is transmitted from the producer cluster to a consumer cluster, where a determination is made whether to apply the binary change log based on the included sequence number. The binary change log is then applied to a database partition in the consumer cluster. The sequence number is stored at the consumer cluster by combining the sequence number with a numerical range having a first number and a second number, where the second number has a value corresponding to the most recent binary change log applied to the database partition in the consumer cluster.

US Patent:

20150185474, Jul 2, 2015

Filed:

Jul 15, 2013

Appl. No.:

14/414919

Inventors:

- Boston MA, US
Thomas Bifano - Mansfield MA, US
Selim M. Unlu - Jamaica Plain MA, US
Euan Ramsay - Dublin CA, US
Fatih Hakan Koklu - Sunnyvale CA, US
Jerome Mertz - Cambridge MA, US
Yang Lu - Boston MA, US
Abdulkadir Yurt - Brighton MA, US
Christopher Stockbridge - Natick MA, US

International Classification:

G02B 27/00
G02B 21/00
G02B 21/33
G02B 21/06
G02B 21/04
G02B 26/08

Abstract:

A system and method for correction of aberrations in a solid immersion microscopy system using a deformable mirror. A solid immersion lens is provided having a surface configured to make optical contact with a nearly planar surface of a substrate, an object to be imaged disposed on the opposite side of the substrate. A convex surface of the solid immersion lens faces an objective lens. A deformable mirror assembly, including a plurality of individually controllable actuators, receives light transmitted from the object. A control system controls in communication with the deformable mirror assembly provides individual actuation of each of the actuators of the deformable mirror to compensate or counteract the effects of aberrations.