Yi L Liu

US Patent:

6343511, Feb 5, 2002

Filed:

Aug 9, 1999

Appl. No.:

09/370767

Inventors:

Lawrence C. Lynnworth - Waltham MA
Yi Liu - Bolton MA

Assignee:

Panametrics, Inc. - Waltham MA

International Classification:

G01N 2928

US Classification:

73644, 7386118

Abstract:

An encapsulated or rigid bundle of rods forms a substantially non-dispersive buffer usable in extreme environments, operable over wide bandwidth, and repairable in the field. The rigid assembly extends through a nozzle or flanged pipe penetration to launch its signals directly in the fluid at a defined angle. The bundles are non-degrading wave guides to carry signals through degrading environments. This is useful for numerous stack, freestream and chordal path configurations, as well as clamp-on systems and special mode-converting configurations. Beam shaping and steering may be passively effected with patterned bundle constructions, and plural faces, which may be stepped or angled, may define multiple oblique, reflective or different length paths while mounted in spoolpieces at normal incidence.

US Patent:

6349599, Feb 26, 2002

Filed:

May 2, 2000

Appl. No.:

09/563474

Inventors:

Lawrence C. Lynnworth - Waltham MA
Yi Liu - Bolton MA

Assignee:

Panametrics, Inc. - Waltham MA

International Classification:

G01N 2900

US Classification:

73644

Abstract:

An ultrasonic coupling assembly includes a barrier layer that contacts the wall, and a generally thicker layer formed of a compliant material such as zinc foil that extends over the first layer. A third layer may cover and enclose the compliant layer, e. g. , by folding the first layer over and on top of the second layer to cover the edge faces thereof. An exemplary embodiment is implemented using gold foil approximately one mil thick for the first layer, and zinc sheeting approximately four mils thick for the second layer. Use of inert top and bottom, or outside, layers prevents the inadvertent installation of the coupling element with the compliant layer directly contacting the wall. Disk embodiments may employ a stack of separate disks formed of foils or sheets of the respective materials. For cryogenic applications, a material such as indium may be used for the second layer without risk of its alloying or migration through the first layer.

US Patent:

6639087, Oct 28, 2003

Filed:

Aug 22, 2002

Appl. No.:

10/225902

Inventors:

Jay F. Larrow - Wakefield MA
Serge Jasmin - Watertown MA
Yi Liu - Weymouth MA
Marcello Di Mare - Belmont MA

Assignee:

Rhodia Pharma Solutions Inc. - Cranbury NJ

International Classification:

C07D30132

US Classification:

549541, 549513, 549540, 502150, 502170, 502171

Abstract:

A method for stereoselective chemical synthesis, includes the steps of: (A) reacting a nucleophile and chiral or prochiral cyclic subtrate, said substrate comprising a carbocycle or a heterocycle having a reactive center susceptible to nucleophilic attack by the nucleophile, in the presence of a chiral non-racemic catalyst to produce a product mixture comprising a stereomerically enriched product wherein the product mixture further comprises a catalyst residue, at least a portion of the catalyst residue is in a first oxidation state, and the catalyst residue in the first oxidation state is active in catalyzing degradation of the stereoisomerically enriched product, and (B) chemically or electochemically changing the oxidation state of the catalyst residue from the first oxidation state to a second oxidation state, wherein catalyst residue in the second oxidation state is less active in catalyzing degradation of the stereoisomerically enriched product than is catalyst residue in the first oxidation state. The method reduces erosion of the chiral purity of the stereoisomerically enriched product and reduces the chemical transformation to side products of the stereoisomerically enriched product and co-product(s). The deactivated catalyst is recoverable and recyclable.

US Patent:

6693206, Feb 17, 2004

Filed:

Aug 22, 2002

Appl. No.:

10/225869

Inventors:

Yi Liu - Weymouth MA
Marcello DiMare - Belmont MA
Salvatore Anthony Marchese - Malden MA
Eric N. Jacobsen - Boston MA
Serge Jasmin - Watertown MA

Assignee:

Rhodia Chirex, Inc. - MA

International Classification:

C07D30132

US Classification:

549541, 549513, 549540

Abstract:

The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(III) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.

US Patent:

6826965, Dec 7, 2004

Filed:

Oct 30, 2000

Appl. No.:

09/702074

Inventors:

Yi Liu - Bolton MA

Assignee:

Panametrics, Inc. - Waltham MA

International Classification:

G01F 166

US Classification:

7386129, 7386131, 7386118

Abstract:

A tag flow measurement system wherein a first and a second measurement path are provided across a flowing fluid, and a receiver in each path receives signals modulated by scatters in the fluid. The direction of signal propagation in one path faces in an opposite sense to, e. g. , is anti-parallel to, the direction of propagation in the other path, and the two receiver outputs are correlated to determine a time interval representative of flow velocity. In one embodiment each path is defined by a transmitter on one side of the conduit and a receiver on the other side of the conduit, and the positions or orientations of transmitter and receiver are reversed in the second pair. Thus, the first transmitter may lie on the same side of the conduit as the second receiver, and the second transmitter may lie on the same side of the conduit as the first receiver. Diametral or chordal paths may be used. A prototype clamp on system detects flowing air at atmospheric pressure in a schedule one inch steel pipe over an extended range, at flow rates as low as several meters per second.

US Patent:

7016788, Mar 21, 2006

Filed:

Jul 6, 2001

Appl. No.:

09/900621

Inventors:

Joel S. Bader - Stamford CT, US
Yi Liu - San Diego CA, US
Darius M. Dziuda - North Haven CT, US

Assignee:

CuraGen Corporation - Branford CT

International Classification:

G01N 33/48
G06F 19/00

US Classification:

702 19, 702 20

Abstract:

The present invention provides novel methods to identify, classify, quantify and compare nucleic acids and polypeptides.

US Patent:

7189729, Mar 13, 2007

Filed:

Sep 30, 2004

Appl. No.:

10/956412

Inventors:

Greg Chopiuk - San Diego CA, US
Pascal Furet - Thann, FR
Nathanael Schiander Gray - San Diego CA, US
Patricia Imbach - Kaiseraugst, CH
Yi Liu - San Diego CA, US
Joseph Schoepfer - Riehen, CH
Ruo Steensma - La Jolla CA, US

Assignee:

IRM LLC - Hamilton

International Classification:

C07D 239/42
C07D 403/12
A61K 31/506
A61P 19/02
A61P 35/00

US Classification:

514256, 544326, 544328, 544333

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

US Patent:

7220818, May 22, 2007

Filed:

Aug 16, 2004

Appl. No.:

10/919659

Inventors:

J. Fraser Stoddart - Los Angeles CA, US
Alexander Star - Pittsburgh PA, US
Yi Liu - San Diego CA, US
Ludek Ridvan - Prague, CZ

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C08G 75/00

US Classification:

528377, 528 86, 429212, 429213, 429209

Abstract:

Nanotubes are treated with poly{(5-alkoxy-m-phenylenevinylene)-co-[(2,5-dioctyloxy-p-phenylene)vinylene]} (PAmPV) polymers and derivatives thereof to provide noncovalent functionalization of the nanotubes which increases solubility and enhances other properties.