Yi Liu

US Patent:

7220818, May 22, 2007

Filed:

Aug 16, 2004

Appl. No.:

10/919659

Inventors:

J. Fraser Stoddart - Los Angeles CA, US
Alexander Star - Pittsburgh PA, US
Yi Liu - San Diego CA, US
Ludek Ridvan - Prague, CZ

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C08G 75/00

US Classification:

528377, 528 86, 429212, 429213, 429209

Abstract:

Nanotubes are treated with poly{(5-alkoxy-m-phenylenevinylene)-co-[(2,5-dioctyloxy-p-phenylene)vinylene]} (PAmPV) polymers and derivatives thereof to provide noncovalent functionalization of the nanotubes which increases solubility and enhances other properties.

US Patent:

8010176, Aug 30, 2011

Filed:

Mar 30, 2007

Appl. No.:

11/731624

Inventors:

Lizhi Sun - Irvine CA, US
Yi Liu - Indianapolis IN, US
Zhiguo Wang - Iowa City IA, US
Ge Wang - Blacksburg VA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 5/00

US Classification:

600407, 600425, 600473, 382128, 382131, 382132, 378 37

Abstract:

A method for obtaining a distribution of a stiffness property in tissue includes applying a plurality of loadings to the tissue, obtaining a plurality of two-dimensional (2-D) imaging projections of the tissue from different directions, measuring a force resulting from one of the plurality of loadings, measuring from at least one of the plurality of 2-D imaging projections a displacement of the tissue in response to the force, obtaining an initial set of input parameters for an estimated stiffness property of the tissue, and solving iteratively for the stiffness property using a computer.

US Patent:

8101608, Jan 24, 2012

Filed:

Nov 7, 2005

Appl. No.:

11/718886

Inventors:

Yongqin Wan - Irvine CA, US
Yuan Mi - San Diego CA, US
Yi Fan - Poway CA, US
Dai Cheng - San Diego CA, US
Yi Liu - San Diego CA, US
Nathanael S. Gray - Boston MA, US
Pamela Albaugh - Carlsbad CA, US

Assignee:

IRM LLC, a Delware Limited Corporation - Hamilton

International Classification:

A61K 31/404
A61K 31/4025
A61K 31/4178
A61K 31/4245
A61K 31/454
A61K 31/5377
A61K 31/496
C07D 401/14
C07D 403/14
C07D 405/06
C07D 405/14
C07D 413/06
C07D 413/14
C07D 471/04

US Classification:

5142352, 514339, 514397, 51425409, 514364, 514414, 548468, 5483121, 5482664, 546201, 544373, 544144

Abstract:

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

US Patent:

8546108, Oct 1, 2013

Filed:

Jan 24, 2011

Appl. No.:

13/575222

Inventors:

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Assignee:

Allergan, Inc. - Irvine CA

International Classification:

C12N 9/52

US Classification:

435 711, 435 691, 435220, 435471

Abstract:

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

US Patent:

20030034489, Feb 20, 2003

Filed:

Jul 16, 2002

Appl. No.:

10/195527

Inventors:

Surya Bhattacharya - Irvine CA, US
Ming Chen - Newport Coast CA, US
Liming Tsau - Irvine CA, US
Henry Chen - Irvine CA, US
Neal Kistler - Monarch Beach CA, US
Yi Liu - Union City CA, US
Tzu-Hsin Huang - San Jose CA, US

Assignee:

Broadcom Corporation

International Classification:

H01L023/58

US Classification:

257/048000

Abstract:

A semiconductor wafer configured for in-process testing of integrated circuitry fabricated thereon. At least two die are separated by a scribe area, and each of the die has at least one complementary metal oxide silicon (CMOS) static random access memory (SRAM) array embedded therein among mixed-signal CMOS circuitry. The mixed-signal CMOS circuitry includes devices with larger feature sizes compared to similar devices of the embedded SRAM array. A first process control monitor (PCM) testline is included, which has a first layout corresponding to the mixed-signal CMOS circuitry. Additionally, a second PCM testline is included, which has a second layout corresponding to the embedded SRAM arrays. The first and second PCM testlines are formed in the scribe area.

US Patent:

20070117964, May 24, 2007

Filed:

Jan 16, 2007

Appl. No.:

11/653364

Inventors:

J. Stoddart - Los Angeles CA, US
Alexander Star - Pittsburgh PA, US
Yi Liu - San Diego CA, US
Ludek Ridvan - Praha, CZ

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C08G 75/32

US Classification:

528377000

Abstract:

Nanotubes are treated with poly{(5-alkoxy-m-phenylenevinylene)-co-[(2,5-dioctyloxy-p-phenylene)vinylene]} (PAmPV) polymers and derivatives thereof to provide noncovalent functionalization of the nanotubes which increases solubility and enhances other properties.

US Patent:

20110189162, Aug 4, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970239

Inventors:

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Assignee:

ALLERGAN, INC. - Irvine CA

International Classification:

A61K 38/48
C07H 21/00
A61K 8/66
A61Q 19/08
A61P 29/00
C12N 15/63
C12N 9/52

US Classification:

424 9467, 536 232, 4353201, 435220

Abstract:

The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins.

US Patent:

20110269779, Nov 3, 2011

Filed:

Nov 17, 2009

Appl. No.:

13/127973

Inventors:

Troy Edward Wilson - San Marino CA, US
Christian Rommel - La Jolla CA, US
Yi Liu - San Diego CA, US
Pingda Ren - San Diego CA, US

Assignee:

INTELLIKINE, INC. - La Jolla CA

International Classification:

A61K 31/519
A61K 31/436
A61P 27/02
C12N 5/02

US Classification:

5142621, 435375, 514291, 5142641

Abstract:

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating signal transduction by certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PB kinase in an ocular tissue. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.