Yi Liu

US Patent:

7375203, May 20, 2008

Filed:

Apr 6, 2005

Appl. No.:

11/099855

Inventors:

Christopher M. Flores - Lansdale PA, US
Yi Liu - Jenkintown PA, US
Mary Lou Lubin - Norristown PA, US
Ning Qin - Blue Bell PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07H 21/02
C07H 21/04

US Classification:

536 231, 536 232, 536 234, 536 235

Abstract:

The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.

US Patent:

7575882, Aug 18, 2009

Filed:

Oct 30, 2006

Appl. No.:

11/589340

Inventors:

Ning Qin - Blue Bell PA, US
Yi Liu - Jenkintown PA, US
Christopher M. Flores - Lansdale PA, US
Tasha Hutchinson - Green Lane PA, US
Michael P. Neeper - Collegeville PA, US

Assignee:

Janssen Pharmaceutica N. V. - Beerse

International Classification:

G01N 33/567
C07K 14/705

US Classification:

435 721, 435 72

Abstract:

It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

US Patent:

8562809, Oct 22, 2013

Filed:

Oct 2, 2009

Appl. No.:

13/122403

Inventors:

Yi Liu - Bethesda MD, US
Gregory F. Payne - Hunt Valley MD, US
W. Lee Meyer - Baltimore MD, US

Assignee:

University of Maryland, College Park - College Park MD

International Classification:

C25D 9/02

US Classification:

205229, 205317

Abstract:

A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electrodepositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like.

US Patent:

20090275649, Nov 5, 2009

Filed:

Jul 9, 2009

Appl. No.:

12/499891

Inventors:

Ning Qin - Blue Bell PA, US
Yi Liu - Jenkintown PA, US
Christopher M. Flores - Lansdale PA, US
Tasha Hutchinson - Green Lane PA, US
Michael P. Neeper - Collegeville PA, US

International Classification:

A61K 31/352
G01N 33/53
C12Q 1/02
C12P 21/02
C12N 5/10
C12N 1/21
C12N 1/15
C12N 15/63
A61K 31/192
A61K 31/05
C07K 14/00
C07H 21/00

US Classification:

514454, 435 721, 435 29, 435 691, 435325, 4352523, 43525411, 4353201, 514568, 514729, 530350, 536 231

Abstract:

It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

US Patent:

20120103822, May 3, 2012

Filed:

Apr 27, 2010

Appl. No.:

13/266433

Inventors:

Yi Liu - Bethesda MD, US
Gregory F. Payne - Hunt Valley MD, US
Xiaohua Yang - Ardmore OK, US

Assignee:

UNIVERSITY OF MARYLAND COLLEGE PARK - College Park MD

International Classification:

C25D 9/02
G01N 33/53
C12N 13/00

US Classification:

205317, 4351731, 435 71

Abstract:

Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling.

US Patent:

20190392516, Dec 26, 2019

Filed:

Sep 5, 2019

Appl. No.:

16/561214

Inventors:

- McLean VA, US
Megan EDDS - Glen Allen VA, US
Keith BARRON - Henrico VA, US
Ashley GIBBS - Richmond VA, US
Matthew VISCHULIS - Vienna VA, US
Carl ASHBY - Montpelier VA, US
Baining HU - Vienna VA, US
Yi LIU - Oakton VA, US
David SCHARDT - Henrico VA, US

Assignee:

Capital One Services, LLC - McLean VA

International Classification:

G06Q 40/02

Abstract:

Systems and methods for providing a separate interest rate for an individual transaction are disclosed. A system may provide a service associated with a account having an account balance and an associated first interest rate. The system may include a service device having one or memory devices storing instructions and one or more processors configured to execute the instructions to perform a separate interest rate service process. The process may include providing a separate interest rate service offer to a client device and receiving a separate interest rate selection from the client device. The process may also include determining a selected portion of the account balance corresponding to an amount to which a second interest rate, different from the first interest rate, is to be applied based on the separate interest rate selection.

US Patent:

20190350817, Nov 21, 2019

Filed:

May 17, 2019

Appl. No.:

16/414986

Inventors:

- York PA, US
Christos Angeletakis - Bear DE, US
Yi Liu - Dover DE, US
Joachim E. Klee - Radolfzell, DE
Christoph Weber - Konstanz, DE
Xin Huo - Dover DE, US

Assignee:

DENTSPLY SIRONA Inc. - York PA

International Classification:

A61K 6/10
C08F 283/12

Abstract:

A light-curable dental impression material comprising(b) a particulate filler; and(c) a photoinitiator.

US Patent:

20190167116, Jun 6, 2019

Filed:

Nov 15, 2018

Appl. No.:

16/192229

Inventors:

Yu Chen - College Park MD, US
Qinggong Tang - College Park MD, US
Udayakumar Kanniyappan - Hyattsville MD, US
Lin Z. Li - Aston PA, US
He Xu - Lansdowne PA, US
Yi Liu - College Park MD, US
Emily Conant - Philadelphia PA, US

International Classification:

A61B 5/00
A61B 1/07
A61B 1/04
A61B 1/06
A61B 1/00
A61B 10/02

Abstract:

In accordance with aspects of the present disclosure, an exemplary system includes a hollow probe having a lumen containing one or more excitation optical fiber(s) and one or more imaging optical fiber(s) where the probe is sized to access a person's body, a first light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of NADH in breast tissue, a second light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of FAD in tissue such as breast tissue, an image capturing device optically coupled to the imaging fiber(s), and a controller configured to control the first light source and the image capturing device to capture NADH fluorescence signals/intensities while the probe is within the person's body and control the second light source and the image capturing device to capture FAD fluorescence signals/intensities while the probe is within the person's body.