Yu Chun Liu

US Patent:

6465692, Oct 15, 2002

Filed:

Dec 22, 1999

Appl. No.:

09/469675

Inventors:

M. Parameswara Reddy - Brea CA
Chitra K. Ratnayake - Yorba Linda CA
Yu Liu - Rowland Heights CA
Jirong Gu - Irvine CA

Assignee:

Beckman Coulter, Inc. - Fullerton CA

International Classification:

C07C23303

US Classification:

564215, 564216, 514629, 204451

Abstract:

Formamide with low conductivity and a neutral or slightly basic pH is provided. Such formamide may be used in a sample loading solution for capillary electrophoretic separation of biomolecular analytes to enhance the efficiency of sample injection into the capillary and the intensity of the signal. Formamide of the present invention may be obtained by first purifying the formamide to a conductivity of below 7 micro mho, and then adjusting the pH of the purified formamide with a base to a range of about pH 6. 5 to 7. 5. The purification may be carried out by first removing the water from the formamide, and then distilling the dried formamide until the conductivity of formamide is below about 7 micro mho.

US Patent:

7381317, Jun 3, 2008

Filed:

Jun 27, 2003

Appl. No.:

10/607584

Inventors:

Yu Liu - Diamond Bar CA, US
M. Parameswara Reddy - Brea CA, US
Chitra K. Ratnayake - Yorba Linda CA, US
Edward V. Koh - Diamond Bar CA, US

Assignee:

Beckman Coulter, Inc. - Fullerton CA

International Classification:

G01N 27/453

US Classification:

204605, 204455

Abstract:

This invention relates to improved methods and compositions for conducting Capillary Electrophoresis (CE) to separate molecules on the basis of their respective size or charge.

US Patent:

7968701, Jun 28, 2011

Filed:

Aug 18, 2008

Appl. No.:

12/193600

Inventors:

Yu Liu - Brooklyn NY, US
Liang Ding - Ithaca NY, US
Ruojie Sha - Pomona NY, US
Nadrian Seeman - New York NY, US
James Canary - New York NY, US

Assignee:

New York University - New York NY

International Classification:

C07H 21/00

US Classification:

536 253, 536 221, 536 231

Abstract:

The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I).

US Patent:

8509577, Aug 13, 2013

Filed:

Jul 2, 2010

Appl. No.:

12/829787

Inventors:

Yu Liu - Irvine CA, US

Assignee:

St. Jude Medical, Inc. - St Paul MN

International Classification:

G02B 6/26

US Classification:

385 27, 385 33, 385 34, 385 39

Abstract:

Embodiments of the invention provide a fiberoptic device that uses a gradient-index (GRIN) lens for focusing a light beam emitted by an optical fiber, but achieves a substantially longer focal length than that of a GRIN lens alone by placing a beam expander (e. g. , no core fiber or step-index multimode fiber) between the terminal end of the optical fiber and the GRIN lens to simulate free space therebetween. In one embodiment, a fiberoptic device comprises an optical fiber having a fiber core and an end through which a light beam emits from the fiber core; a beam expander having a first end coupled to the end of the optical fiber and having a second end, the beam expander permitting the light beam emitting from the fiber core to pass from the first end to the second end and to expand from the first end to a larger size at the second end; and a gradient-index fiber lens coupled to the second end of the beam expander to receive the light beam from the beam expander and focus the light beam.

US Patent:

20090314638, Dec 24, 2009

Filed:

May 12, 2008

Appl. No.:

12/119363

Inventors:

Yu Liu - Diamond Bar CA, US
M. Parameswara Reddy - Brea CA, US
Chitra K. Ratnayake - Yorba Linda CA, US
Edward V. Koh - Diamond Bar CA, US

Assignee:

Beckman Coulter, Inc. - Fullerton CA

International Classification:

B01D 57/02
C07K 1/26

US Classification:

204455, 204605

Abstract:

This invention relates to improved methods and compositions for conducting Capillary Electrophoresis (CE) to separate molecules on the basis of their respective size or charge.

US Patent:

20100041986, Feb 18, 2010

Filed:

Jul 23, 2009

Appl. No.:

12/508000

Inventors:

Tho Hoang NGUYEN - Huntington Beach CA, US
Peter C. CHEN - Irvine CA, US
Alan DE LA RAMA - Cerritos CA, US
Yu LIU - Irvine CA, US

International Classification:

A61B 6/02
A61B 18/14

US Classification:

600427, 606 33

Abstract:

An ablation and monitoring system comprises a catheter, an optical coherence tomography (OCT) system, and an ablation generator. The catheter comprises one or more optical fibers to transmit a light beam to a tissue material and collect a reflected light from the tissue material. The OCT system is in optical communication with the catheter via the one or more optical fibers, providing the light beam to the one or more optical fibers and receiving the reflected light from the one or more optical fibers. The ablation generator is in electrical communication with the OCT system and with the catheter. The ablation generator provides radio frequency energy to the catheter for ablating the tissue material, monitors and assesses the ablation based on an information signal received from the OCT system.

US Patent:

20120229812, Sep 13, 2012

Filed:

Mar 7, 2011

Appl. No.:

13/041559

Inventors:

Yu LIU - Irvine CA, US

Assignee:

ST. JUDE MEDICAL, INC. - St. Paul MN

International Classification:

G01B 9/02

US Classification:

356477

Abstract:

A signal interrogation system comprises an optical coupler to split input laser beam into a first laser beam as a power reference and a second laser beam, the optical coupler being coupled to a first path for the first laser beam and a second path for the second laser beam; an optical circulator disposed in the second path; a bi-directional optical switch disposed in the second path and having on one side a single channel end oriented toward the optical circulator and on another side multiple channel ends with multiple switchable channels; a plurality of optical fibers coupled to the multiple channel ends of the bi-directional optical switch; an interference optical signals path coupled to the optical circulator to receive the interference optical signals from the bi-directional switch; and a balanced photo detector to measure a power difference between the interference optical signals and the power reference.

US Patent:

20120232821, Sep 13, 2012

Filed:

Mar 7, 2011

Appl. No.:

13/041576

Inventors:

Yu LIU - Irvine CA, US

Assignee:

ST. JUDE MEDICAL, INC. - St. Paul MN

International Classification:

G06F 19/00
G01R 23/16

US Classification:

702 77

Abstract:

Embodiments of the invention provide multi-channel OCT (Optical Coherence Tomography) for imaging biological tissue or the like, and for temperature and/or force sensing, preferably in real time. In one embodiment, an optical signal processing system comprises: a processor; a memory; a receiving module to receive in real time input from multiple channels of OCT producing interfering optical signals representing multiple measured distances for a target imaging object; a Fast Fourier Transform (FFT) module to apply FFT on the interfering optical signals in real time to produce Fourier frequencies corresponding to the multiple measured distances; and a calculation module to calculate in real time multiple force components of a force applied on the target imaging object to cause at least some of the multiple measured distances for the target imaging object based on the Fourier frequencies from the FFT module.