Yuan C Liu

US Patent:

8226943, Jul 24, 2012

Filed:

Jul 8, 2009

Appl. No.:

12/499627

Inventors:

Austin L. Gurney - San Francisco CA, US
Timothy Charles Hoey - Hillsborough CA, US
Edward Thein Htun van der Horst - Palo Alto CA, US
Aaron Ken Sato - Burlingame CA, US
Yuan Ching Liu - Fremont CA, US
Maureen Fitch Bruhns - San Mateo CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

OncoMed Pharmaceuticals, Inc. - Redwood City CA

International Classification:

A61K 39/395
C07K 16/28
C07K 14/705
C12N 5/00

US Classification:

4241301, 4241331, 4241411, 4241431, 435326, 435331, 435334, 530350, 5303871, 5303881, 53038815, 53038822

Abstract:

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

US Patent:

8425903, Apr 23, 2013

Filed:

May 15, 2012

Appl. No.:

13/472305

Inventors:

Austin L. Gurney - San Francisco CA, US
Timothy Charles Hoey - Hillsborough CA, US
Edward Thein Htun van der Horst - Palo Alto CA, US
Aaron Ken Sato - Burlingame CA, US
Yuan Ching Liu - Fremont CA, US
Maureen Fitch Bruhns - San Mateo CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

OncoMed Pharmaceuticals, Inc. - Redwood City CA

International Classification:

A61K 39/395
A61P 35/00
C07K 16/28

US Classification:

4241301, 4241331, 4241381, 4241411, 4241421, 4241431, 514 133, 514 192, 514 193, 514 194, 5303871, 5303873, 5303877, 5303881, 53038815, 53038822

Abstract:

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

US Patent:

8526946, Sep 3, 2013

Filed:

Jul 10, 2012

Appl. No.:

13/545515

Inventors:

Giridhar Pattaswamy - Karnataka, IN
Navin K. Karra - Bracknell, GB
Abhishek Pandit - Wokingham, GB
Stephen J Richards - Maidenhead, GB
Yuan Liu - Holmdel NJ, US
Yaxin Cao - Laurence Harbor NJ, US
Jun Lin - Cupertino CA, US

Assignee:

Broadcom Corporation - Irvine CA

International Classification:

H04W 4/00

US Classification:

4554351

Abstract:

Systems and methods are presented to support operation of a multiple subscriber identity module (SIM) device. A first SIM may perform a data transfer or voice call. During the first SIM's data transfer or voice call, transition times are identified to transition communication resources to a second SIM for use in performing a registration update communication with a network controller that supports the second SIM. The registration update communication may include a periodic location update, a periodic routing update, or a periodic tracking update. The multiple SIM device may identify the transition time by obtaining periodic registration timing information from the network controller, configuring a periodic registration timer based on the periodic registration timing information, and setting the transition time as an expiration time of the periodic registration timer.

US Patent:

20110117909, May 19, 2011

Filed:

Oct 8, 2010

Appl. No.:

12/901322

Inventors:

Yaxin Cao - Lauence Harbor NJ, US
Yuan Liu - Holmdel NJ, US
Zhijun Gong - Holmdel NJ, US
Yongqian Wang - East Brunswick NJ, US
Xiaoxin Qiu - Basking Ridge NJ, US
Stephen Richards - Maidenhead, GB

International Classification:

H04W 24/00

US Classification:

455423

Abstract:

A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. The access to radio resources in the single radio resource unit is controlled via a virtual modem controller (VMC). The VMC collects performance metrics such as requested service type and signal quality associated with each of the VMs. A VM is selected based on the collected performance metrics to perform a requested service. A serving VM is switched among the VMs based on the collected performance metrics. VM capabilities are dynamically configured based on the collected performance metrics. According to the collected performance metrics such as associated navigation information and requested service type, one or more VMs may be turned on or off, and certain VM capabilities may be enabled or disabled to save resources.

US Patent:

20110117944, May 19, 2011

Filed:

Jun 16, 2010

Appl. No.:

12/816835

Inventors:

Yaxin Cao - Laurence Harbor NJ, US
Xiaoxin Qiu - Basking Ridge NJ, US
Yuan Liu - Holmdel NJ, US
Zhijun Gong - Iselin NJ, US
Yongqian Wang - East Brunswick NJ, US
Stephen Richards - Maidenhead, GB

International Classification:

H04W 72/04

US Classification:

455509

Abstract:

A multiple-subscriber identity module (multi-SIM) multi-standby communication device comprises a single radio resource unit shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. The access to radio resources in the single radio resource unit is controlled for each VM task via a virtual modem controller (VMC). Upon receiving requests for tasks to access radio resources in the single radio resource unit, the VMC arbitrates the access based on task priority information, current activities associated with one or more of the plurality of VMs, and the radio resources available in the single radio resource unit. The access may be immediately accepted, accepted with a delay or rejected. With an immediate access, current activities may be suspended and then resumed once radio resources become available. With a delayed access, the VMC determines what time instants the access may be accepted.

US Patent:

20130148574, Jun 13, 2013

Filed:

May 17, 2012

Appl. No.:

13/474006

Inventors:

Yuan Liu - Holmdel NJ, US
Sethuraman Gurumoorthy - Piscataway NJ, US
Yaxin Cao - Laurance Harbor NJ, US
Giridhar Pattaswamy - Bracknell, GB
Navin K. Karra - Bracknell, GB
Abhishek Pandit - Wokingham, GB
Stephen J. Richards - Maidenhead, GB

Assignee:

BROADCOM CORPORATION - Irvine CA

International Classification:

H04W 28/02

US Classification:

370328

Abstract:

An acknowledgement technique reduces packet-switched communication delays. The technique may be implemented in a mobile communication device with multiple SIMs. The technique facilitates enhanced communication capability for the mobile communication device. In one implementation, the technique helps reduce delays caused by switching between packet-switched and circuit-switched communications. Specifically, in one aspect, the technique reduces delays caused by exponential backoff that may occur during suspension of a packet-switched communication.

US Patent:

20130150013, Jun 13, 2013

Filed:

Jul 11, 2012

Appl. No.:

13/546515

Inventors:

Yuan Liu - Holmdel NJ, US
Jun Lin - Cupertino CA, US
Yaxin Cao - Laurence Harbor NJ, US
Sethuraman Gurumoorthy - Piscataway NJ, US
Tong Chen - Cliffwood NJ, US
Rami Mehio - San Diego CA, US
Jin-Sheng Su - San Diego CA, US
Arun Visvanath - San Diego CA, US

Assignee:

Broadcom Corporation - Irvine CA

International Classification:

H04W 4/00

US Classification:

455418

Abstract:

Systems and methods are presented to support operation of a multiple subscriber identity module (SIM) device. A timing conflict may exist when a scheduled high priority communication of a first SIM overlaps with a scheduled paging monitoring activity for a second SIM. The multiple SIM device may preempt transitioning communication resources to the second SIM when the first SIM executes high priority communications. Or, the multiple SIM device may execute a rescheduling action to resolve the timing conflict. The high priority communication of the first SIM may be rescheduled. Alternatively, normal priority paging monitoring actions may be rescheduled to resolve the timing conflict.

US Patent:

20130260455, Oct 3, 2013

Filed:

Mar 1, 2013

Appl. No.:

13/782671

Inventors:

Timothy Charles Hoey - Hillsborough CA, US
Edward Thein Htun van der Horst - Palo Alto CA, US
Aaron Ken Sato - Burlingame CA, US
Yuan Ching Liu - Fremont CA, US
Maureen Fitch Bruhns - San Mateo CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

OncoMed Pharmaceuticals, Inc. - Redwood City CA

International Classification:

C07K 16/28

US Classification:

435331, 536 2353, 4353201, 43525233, 43525231, 4352542

Abstract:

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.