Yubing Xie from 24 Dutch Meadows Dr, Dunsbach Ferry, NY 12047, age 54

Drug And Gene Delivery By Polymer Nanonozzle And Nanotip Cell Patch
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US Patent:

20080248575, Oct 9, 2008
Filed:

Oct 20, 2006
Appl. No.:

12/090958
Inventors:

L. James Lee - Columbus OH, US
Shengnian Wang - Columbus OH, US
Yubing Xie - Cohoes NY, US
Changchun Zeng - Tallahassee FL, US
Chee Guan Koh - Lewis Center OH, US
Zhengzheng Fei - Columbus OH, US
Assignee:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH
International Classification:

C12N 15/87
B29C 67/24
C12N 5/06
US Classification:

435446, 264225, 435375
Abstract:

Delivery of drugs or genes to individual cells is achieved on a nanoscale using electroporation techniques. In one method, a flow-through bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber is used. Cells to be electroporated are flowed from the inlet to the outlet, a quantum of molecules of the at least one drug or gene in a fluid medium in the flow chamber. An electrical field applied in the flow chamber provides momentum to the molecules in the nanopores, resulting in delivery of the molecules into the plurality of cells.

Bioengineered Human Trabecular Meshwork For Biological Applications
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US Patent:

20140038221, Feb 6, 2014
Filed:

Feb 19, 2013
Appl. No.:

13/771007
Inventors:

Magnus Bergkvist - Albany NY, US
Sara Ann Brenner - Voorheesville NY, US
Ioannis Danias - Staten Island NY, US
Susan Tina Sharfstein - Niskayuna NY, US
Yubing Xie - Cohoes NY, US
International Classification:

G01N 33/483
A61F 9/007
US Classification:

435 29, 435402, 4352873, 604 8
Abstract:

The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.

Assemblies Incorporating Biomolecules And/Or Cells With Micro-/Nanostructures, And Methods Of Making The Same For Biological Applications
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US Patent:

20080038710, Feb 14, 2008
Filed:

Jun 1, 2007
Appl. No.:

11/809787
Inventors:

Ly Lee - Columbus OH, US
Yong Yang - Columbus OH, US
Yubing Xie - Columbus OH, US
Douglas Kniss - Hilliard OH, US
Assignee:

The Ohio State University - Columbus OH
International Classification:

C12N 5/06
A01N 1/00
US Classification:

435001100, 435395000
Abstract:

Assemblies incorporating cells, biologically active molecules, or combinations thereof. Three dimensional tissue scaffolds are used in the assemblies. The three dimensional tissue scaffolds include a plurality of scaffold layers seeded with cells, biologically active molecules, or combinations thereof, the plurality of cell scaffold layers stacked one on top of another and bonded together in the absence of a solvent or an adhesive. Methods of making the assemblies are also disclosed.

Compositions, Apparatuses And Methods For Making And Using Bioscaffolds
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US Patent:

20220195387, Jun 23, 2022
Filed:

Dec 21, 2021
Appl. No.:

17/558543
Inventors:

- Albany NY, US
Yubing Xie - Cohoes NY, US
James Castracane - Marshfield NY, US
Melinda Larsen - Albany NY, US
International Classification:

C12N 5/071
D01D 5/00
Abstract:

The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics.

Yubing Xie