Yunbiao Lu

age ~64

from North Potomac, MD

Also known as:
  • Yang Lu
  • Yan G Lu
  • Lu Yang Yunbiao
  • Biao Lu Yun

Yunbiao Lu Phones & Addresses

  • North Potomac, MD
  • 564 Prospect St, New Haven, CT 06511
  • 575 Prospect St, New Haven, CT 06511
  • 36 Landin St, Woodbridge, CT 06525
  • Rockville, MD

Industries

Biotechnology

Resumes

Yunbiao Lu Photo 1

Biotechnology Professional

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Location:
Washington D.C. Metro Area
Industry:
Biotechnology

Us Patents

  • Specific Bifunctional By-001 (Active Composition Of Homomultimer Of Chimeric Protein Pd-L1 / Fc-Gamma1) Down Regulates The Activation Of Human Immune Cells And The Use Thereof

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  • US Patent:
    20190241643, Aug 8, 2019
  • Filed:
    Nov 14, 2018
  • Appl. No.:
    16/190641
  • Inventors:
    Yunbiao Lu - North Potomac MD, US
  • International Classification:
    C07K 14/705
    A61K 35/17
    C07K 14/735
    A61K 47/68
    A61P 37/06
  • Abstract:
    The present invention provides an active form (BY-001) of a homomultimeric chimeric protein PD-L1/Fc-gamma1, which may have a composition of 25% dimer, 30% tetramer and 45% hexamer. BY-001 consists of two distinct functional domains at the aggregated state, one is the extracellular domain of PD-L1 and another one is the IgG1 Fc region. Accordingly, the first functional domain of PD-L1 at its aggregated state is more effective in suppressing the activity of CD3+ and CD28+ T cells; while, on the other hand, the second functional domain of FC-gamma1 at its aggregated state exerts only the suppressive effects on the immune cell bearing the Fc-gamma receptors. Thus, the features provided in present invention indicate that BY-001 regulates the functions of immune cells subsets that are responsible for the peripheral immune tolerance, which makes BY-001 potential to help restore or maintain the peripheral immune tolerance in patients with autoimmune diseases or in recipients of allografts.

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