Zheng M Liu

US Patent:

20130296554, Nov 7, 2013

Filed:

Mar 13, 2013

Appl. No.:

13/799479

Inventors:

Zheng Liu - Beacon Falls CT, US
Jacob Swidorski - Southington CT, US
Jie Chen - Madison CT, US
Yan Chen - Wallingford CT, US
Nicholas A. Meanwell - East Hampton CT, US
Alicia Regueiro-Ren - Middletown CT, US

International Classification:

C07D 487/08
C07D 495/08
C07D 495/10
C07D 487/10
C07D 498/08
C07D 209/52
C07D 491/08

US Classification:

544105, 548452, 548453, 548409, 548950, 546 16

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.

US Patent:

20210360587, Nov 18, 2021

Filed:

May 17, 2021

Appl. No.:

17/322826

Inventors:

- Falls Church VA, US
Zheng Liu - Chantilly VA, US
Mahmoud Khafagy - Falls Church VA, US

International Classification:

H04W 72/00
H04B 7/185
H04W 12/73
H04L 5/00

Abstract:

An electronic user device includes inclusion list storage with electronically readable memory, for storing an inclusion list and the inclusion list indicating included logical IDs. The device also has a security module app that receives a cellular broadcast message and extracts logical IDs therefrom. This processes a targeted cellular broadcast message embedded in the payload of the cellular broadcast message, based on whether a logical ID, also embedded in the payload, of the targeted cellular broadcast message is on the inclusion list. It then formats it for consumption by an electronic user device app that receives data via a data channel when available.

US Patent:

20180079814, Mar 22, 2018

Filed:

Mar 31, 2016

Appl. No.:

15/562247

Inventors:

- Cambridge, GB
Philip Z. Brohawn - Gaithersburg MD, US
Wei Zhu - Gaithersburg MD, US
Zheng Liu - Gaithersburg MD, US
Jiaqi Huang - Gaithersburg MD, US
Katie Streicher - Gaithersburg MD, US
Yihong Yao - Gaithersburg MD, US

International Classification:

C07K 16/28
C12Q 1/6886
A61P 35/00

Abstract:

A method for treating lung cancer (e.g., non-small cell lung cancer) with an anti-PD-L1 antibody (MEDI4736), alone or in combination with an anti-CTLA4 antibody (Tremelimumab), in a patient identified using a polynucleotide marker of IFNgamma.

US Patent:

20170204133, Jul 20, 2017

Filed:

Jun 17, 2015

Appl. No.:

15/313139

Inventors:

- Brentford, Middlesex, GB
Animesh GOSWAMI - New Brunswick NJ, US
Zhiwei GUO - Sammamish WA, US
Thomas P. TULLY - New Brunswick NJ, US
Jacob SWIDORSKI - Wallingford CT, US
Zheng LIU - Wallingford CT, US
Nicholas A. MEANWELL - Wallingford CT, US

International Classification:

C07J 63/00
C07J 71/00

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.

US Patent:

20160151387, Jun 2, 2016

Filed:

Feb 4, 2016

Appl. No.:

15/015741

Inventors:

- Princeton NJ, US
Zheng Liu - Beacon Falls CT, US
Jacob Swidorski - Southington CT, US
Ny Sin - East Hampton CT, US
Brian Lee Venables - Durham CT, US
Yan Chen - Guilford CT, US
Jie Chen - Madison CT, US
Nicholas A. Meanwell - East Hampton CT, US

International Classification:

A61K 31/565
A61K 31/58
A61K 31/704
A61K 45/06

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.

US Patent:

20140343000, Nov 20, 2014

Filed:

Jul 24, 2014

Appl. No.:

14/339572

Inventors:

- Princeton NJ, US
Zheng Liu - Beacon Falls CT, US
Jacob Swidorski - Southington CT, US
Ny Sin - East Hampton CT, US
Brian Lee Venables - Durham NC, US
Yan Chen - Guildford CT, US
Jie Chen - Madison CT, US
Nicholas A. Meanwell - East Hampton CT, US

International Classification:

C07J 63/00
A61K 31/56
A61K 45/06
A61K 31/58

US Classification:

514 25, 514567, 514565, 514566, 5142378, 514319, 5142541, 5142275, 514218, 514400, 51421017, 514370, 514352, 514349

Abstract:

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.