Zhiren Liu

US Patent:

20110097742, Apr 28, 2011

Filed:

Apr 2, 2009

Appl. No.:

12/935413

Inventors:

Jenny Jie Yang - Atlanta GA, US
Zhiren Liu - Atlanta GA, US
Shunyi Li - Atlanta GA, US
Yubin Zhou - San Diego CA, US
Jie Jiang - Atlanta GA, US
Shenghui Xue - Atlanta GA, US
Jinjuan Qiao - Atlanta GA, US
Lixia Wei - Atlanta GA, US

International Classification:

G01N 33/53
C07K 14/00
C07K 16/18

US Classification:

435 721, 530400, 5303873

Abstract:

Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.

US Patent:

20210038745, Feb 11, 2021

Filed:

Oct 12, 2020

Appl. No.:

17/068215

Inventors:

- Atlanta GA, US
Zhiren LIU - Atlanta GA, US
Jie JANG - Atlanta GA, US
Shenghui XUE - Atlanta GA, US
Jinjuan QIAO - Atlanta GA, US
Mani SALARIAN - Decatur GA, US

International Classification:

A61K 49/14
A61K 49/12

Abstract:

Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.

US Patent:

20180250426, Sep 6, 2018

Filed:

Mar 2, 2018

Appl. No.:

15/910893

Inventors:

- Atlanta GA, US
Zhiren Liu - Atlanta GA, US
Shunyi Li - Atlanta GA, US
Yubin Zhou - San Diego CA, US
Jie Jiang - Atlanta GA, US
Shenghui Xue - Atlanta GA, US
Jinjuan Qiao - Atlanta GA, US
Lixia Wei - Atlanta GA, US

International Classification:

A61K 49/14
A61K 49/12

Abstract:

Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.

US Patent:

20150202330, Jul 23, 2015

Filed:

Jun 5, 2013

Appl. No.:

14/405623

Inventors:

- Atlanta GA, US
Zhiren Liu - Atlanta GA, US
Shunyi Li - Wuhan, CN
Yubin Zhou - Houston TX, US
Jie Jiang - Atlanta GA, US
Shenghui Xue - Atlanta GA, US
Jingjuan Qiao - Atlanta GA, US
Lixia Wei - Duluth GA, US

International Classification:

A61K 49/14

Abstract:

Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd, each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion; the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image; and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio.