Zihao P Hua from 146 Woburn St, Andover, MA 01810, age 52

Us Patents

Spiro-Tricyclic Ring Compounds As Beta-Secretase Modulators And Methods Of Use
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US Patent:

8426447, Apr 23, 2013
Filed:

Sep 11, 2009
Appl. No.:

12/558426
Inventors:

Ryan White - Somerville MA, US
Albert Amegadzie - Moorpark CA, US
Marian C. Bryan - West Hills CA, US
Jian Jeffrey Chen - Camarillo CA, US
Alan C. Cheng - Cambridge MA, US
Thomas Dineen - Somerville MA, US
Oleg Epstein - Belmont MA, US
Vijay Keshav Gore - Thousand Oaks CA, US
Zihao Hua - Tewksbury MA, US
Jason Brooks Human - Boston MA, US
Hongbing Huang - Lexington MA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Qingyian Liu - Camarillo CA, US
Vu Van Ma - Simi Valley CA, US
Isaac Marx - Cambridge MA, US
Vinod F Patel - Acton MA, US
Wenyuan Qian - Camarillo CA, US
Matthew Weiss - Boston MA, US
Chester Chenguang Yuan - Newbury Park CA, US
Assignee:

Amgen Inc. - Thousand Oaks CA
International Classification:

A61K 31/44
C07D 311/82
C07D 401/00
C07D 413/00
US Classification:

514336, 5462681, 5462714, 549223
Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

Homogeneous Erythropoietin And Other Peptides And Proteins, Methods And Intermediates For Their Preparation
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US Patent:

20100081786, Apr 1, 2010
Filed:

Apr 11, 2007
Appl. No.:

12/296608
Inventors:

Samuel J. Danishefsky - Englewood NJ, US
J. David Warren - Lodi NJ, US
Jiehao Chen - Fishers IN, US
Bin Wu - Thousand Oaks CA, US
Gong Chen - New York NY, US
Qian Wan - New York NY, US
Zhongping Tan - New York NY, US
Cindy Kan - New York NY, US
Yu Yuan - New York NY, US
Zihao Hua - New York NY, US
Krishnakumar Ranganathan - Oak Park CA, US
John D. Trzupek - New York NY, US
International Classification:

C07K 14/505
C07K 1/00
US Classification:

530322, 530333, 530345
Abstract:

The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III)-LH. wherein A and L1 are as defined herein.

Aurora Kinase Modulators And Method Of Use
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US Patent:

7776857, Aug 17, 2010
Filed:

Apr 3, 2008
Appl. No.:

12/080669
Inventors:

Victor Cee - Thousand Oaks CA, US
Holly Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Zihao Hua - Tewksbury MA, US
Matthew Martin - Cambridge MA, US
Isaac Marx - Somerville MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip Olivieri - Charlestown MA, US
Kathleen Panter - Cambridge MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US
Assignee:

Amgen Inc. - Thousand Oaks CA
International Classification:

C07D 237/30
US Classification:

514248, 544237, 546123
Abstract:

The present invention relates to chemical compounds having a general formula I.

Benzimidazole Derivatives And Their Uses
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US Patent:

20200308145, Oct 1, 2020
Filed:

Oct 18, 2018
Appl. No.:

16/754349
Inventors:

- Thousand Oaks CA, US
Nagasree CHAKKA - Lexington MA, US
Hua GAO - Canton MA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Daniel B. HORNE - Natick MA, US
Zihao HUA - Andover MA, US
Madeleine KIEFFER - Burlingame CA, US
Daniel C. H. Lin - Redwood City CA, US
Benjamin Charles MILGRAM - Cambridge MA, US
Jane PANTELEEV - Charlestown MA, US
Laurie SCHENKEL - Somerville MA, US
John STELLWAGEN - Beverly MA, US
Matthew WEISS - Boston MA, US
Ryan D. WHITE - Somerville MA, US
Wei ZHAO - Westford MA, US
Assignee:

Amgen Inc. - Thousand Oaks CA
International Classification:

C07D 401/14
C07D 471/10
C07D 471/04
C07D 498/04
C07D 401/04
C07D 403/04
C07D 413/14
Abstract:

The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Pyrazole Amide Derivative
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US Patent:

20150266824, Sep 24, 2015
Filed:

Feb 27, 2015
Appl. No.:

14/633936
Inventors:

- Thousand Oaks CA, US
- Tokyo, JP
Howard Bregman - Melrose MA, US
Victor J. Cee - Thousand Oaks CA, US
Nagasree Chakka - Lexington MA, US
Timothy D. Cushing - Pacifica CA, US
Oleg Epstein - Belmont MA, US
Brian M. Fox - Brisbane CA, US
Stephanie Geuns-Meyer - Medford MA, US
Xiaolin Hao - Foster City CA, US
Kenta Hibiya - Chiyoda-ku, JP
Jun Kirata - Chiyoda-ku, JP
Zihao Hua - Andover MA, US
Jason Human - Boston MA, US
Shinji Kakuda - Chiyoda-ku, JP
Patricia Lopez - Woodland Hills CA, US
Ryota Nakajima - Chiyoda-ku, JP
Kazuhisa Okada - Chiyoda-ku, JP
Steven H. Olson - Millbrae CA, US
Hiroyuki Oono - Chiyoda-ku, JP
Lewis D. Pennington - Arlington MA, US
Kosuke Sasaki - Chiyoda-ku, JP
Keiko Shimada - Chiyoda-ku, JP
Youngsook Shin - Thousand Oaks CA, US
Ryan D. White - Somerville MA, US
Ryan P. Wurz - Newbury Park CA, US
Shuyan Yi - Malden MA, US
Xiao Mei Zheng - Natick MA, US
International Classification:

C07D 231/14
C07D 409/12
C07D 413/12
C07D 405/14
C07D 401/14
C07D 493/08
C07D 401/12
C07D 403/12
Abstract:

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Amino-Dihydrothiazine And Amino-Dioxido Dihydrothiazine Compounds As Beta-Secretase Antagonists And Methods Of Use
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US Patent:

20150259308, Sep 17, 2015
Filed:

Oct 10, 2013
Appl. No.:

14/433769
Inventors:

- Thousand Oaks CA, US
Jennifer R. Allen - Newbury Park CA, US
Yuan Cheng - Newbury Park CA, US
Deborah Choquette - Medford MA, US
Oleg Epstein - Belmont MA, US
Angel Guzman-Perez - Belmont MA, US
Paul E. Harrington - Camarillo CA, US
Zihao Hua - Andover MA, US
Randall W. Hungate - Longmont CO, US
Jason Brooks Human - Boston MA, US
Ted Judd - Granada Hills CA, US
Qingyian Liu - Camarillo CA, US
Patricia Lopez - Woodland Hills CA, US
Ana Elena Minatti - Santa Monica CA, US
Philip Olivieri - Charlestown MA, US
Karina Romero - Burlington MA, US
Shannon Rumfelt - Camarillo CA, US
Robert M. Rzasa - Ventura CA, US
Laurie Schenkel - Boston MA, US
John Stellwagen - Beverly MA, US
Ryan White - Somerville MA, US
Qiufen Xue - Newbury Park CA, US
Xiao Mei Zheng - Natick MA, US
Wenge Zhong - Thousand Oaks CA, US
Assignee:

AMGEN INC. - Thousand Oaks CA
International Classification:

C07D 279/12
C07D 471/04
C07D 239/74
C07D 495/04
C07D 213/79
C07D 513/10
C07D 417/12
C07D 417/14
C07D 513/04
C07D 498/04
C07D 279/14
C07D 417/04
C07D 241/44
Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, R, R, R, Rand n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Bridged Bicyclic Amino Thiazine Dioxide Compounds As Inhibitors Of Beta-Secretase And Methods Of Use Thereof
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US Patent:

20150252059, Sep 10, 2015
Filed:

May 20, 2015
Appl. No.:

14/717339
Inventors:

- Thousand Oaks CA, US
Jennifer R. ALLEN - Newbury Park CA, US
James BROWN - Moorpark CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Zihao HUA - Andover MA, US
Ted JUDD - Granada Hills CA, US
Qingyian LIU - Camarillo CA, US
Philip R. OLIVIERI - Charlestown MA, US
Karina ROMERO - Burlington MA, US
Laurie SCHENKEL - Boston MA, US
John STELLWAGEN - Beverly MA, US
Ryan WHITE - Somerville MA, US
International Classification:

C07D 513/08
C07D 519/00
Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, R, R, R, Rand n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.

Quinazolinone Compounds And Derivatives Thereof
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US Patent:

20150225396, Aug 13, 2015
Filed:

Aug 27, 2013
Appl. No.:

14/423078
Inventors:

- Thousand Oaks CA, US
John L. Buchanan - Newton MA, US
Nagasree Chakka - Lexington MA, US
Erin F. Dimauro - Cambridge MA, US
Hakan Gunaydin - Somerville MA, US
Angel Guzman-Perez - Belmont MA, US
Zihao Hua - Andover MA, US
Xin Huang - Wellesley MA, US
International Classification:

C07D 471/02
C07D 413/14
C07D 401/14
C07D 239/95
C07D 401/12
C07D 239/90
C07D 417/12
C07D 413/12
C07D 417/14
Abstract:

Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.