Samuel W Brooks

US Patent:

48107000, Mar 7, 1989

Filed:

May 18, 1983

Appl. No.:

6/495221

Inventors:

Samuel C. Brooks - West Bloomfield MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A61K 3156

US Classification:

514178

Abstract:

An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R. sub. 1 is F, Br, NO. sub. 2, or H; R. sub. 2 is F, Br, NO. sub. 2, NH. sub. 2, or H; R is H or alkyl of 1-4 carbon atoms; R. sub. 3 is O or H. sub. 2 ; and R. sub. 4 is H. sub. 2, O, or. alpha. -H,. beta. -OH; R. sub. 5 is H. sub. 2,. alpha. -H and. beta. -OH or B-H and. alpha. -OH in admixture with a pharmaceutically acceptable carrier with the proviso that R. sub. 1, R. sub. 2 and R. sub. 3 cannot all be hydrogen and one of R. sub. 1 and R. sub. 2 is F.

US Patent:

44965559, Jan 29, 1985

Filed:

Jul 19, 1983

Appl. No.:

6/515335

Inventors:

Samuel C. Brooks - Orchard Lake MI
Jerome P. Horwitz - Oak Park MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A61K 3156

US Classification:

514182

Abstract:

The present invention concerns the novel compounds having fluoro, amino, nitro or hydroxy monosubstituted at the 2- or 4- position on deoxyestrone as well as deoxyestra-17-ol. The compounds are useful as estrogen sulfotransferase inhibitors. Such estrogen sulfotransferase inhibition provides the novel use for treating a female mammal to prevent implantation of a blastocyst. Additionally, the invention concerns the novel synthesis and novel intermediates in the synthesis of the estrogen sulfotransferase inhibiting compound of the present invention.

US Patent:

45686734, Feb 4, 1986

Filed:

Mar 20, 1984

Appl. No.:

6/591500

Inventors:

Samuel C. Brooks - Orchard Lake MI
Jerome P. Horwitz - Oak Park MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A61K 3156

US Classification:

514178

Abstract:

A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms or hydroxyalkoxy of 2-4 carbon atoms and Y is nitro, inhibiting the growth of murine ductal carcinoma (MXT mammary tumors).

US Patent:

46686681, May 26, 1987

Filed:

Feb 3, 1986

Appl. No.:

6/825760

Inventors:

Samuel C. Brooks - Orchard Lake MI
Jerome P. Horwitz - Oak Park MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A61K 3156

US Classification:

514178

Abstract:

A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms and Y is amino, inhibits the growth of murine ductal carcinoma (MXT mammary tumors). A compound wherein Z is OH and Y is nitro, administered orally, inhibits the growth of MXT mammary tumors.

US Patent:

46364960, Jan 13, 1987

Filed:

Jan 28, 1986

Appl. No.:

6/823273

Inventors:

Samuel C. Brooks - Orchard Lake MI
Jerome P. Horwitz - Oak Park MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A61K 3156

US Classification:

514182

Abstract:

A compound of the formula ##STR1## wherein Z is hydrogen and Y is nitro, inhibits the growth of murine ductal carcinoma (MXT mammary tumors).

US Patent:

43406025, Jul 20, 1982

Filed:

Oct 18, 1978

Appl. No.:

5/952592

Inventors:

Samuel C. Brooks - Detroit MI

Assignee:

Wayne State University - Detroit MI

International Classification:

A01N 4500
A61K 3156

US Classification:

424238

Abstract:

An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R. sub. 1 is Br, NO. sub. 2, or H; R. sub. 2 is Br, NO. sub. 2, NH. sub. 2, or H; R is H or alkyl of 1-4 carbon atoms; R. sub. 3 is O or H. sub. 2 ; and R. sub. 4 is H. sub. 2, O, or. alpha. -H,. beta. -OH, in admixture with a pharmaceutically acceptable carrier. The specificity of the invention is believed targeted to the substituent at R. sub. 2 or C. sub. 4 and secondarily the OR group at C. sub. 3.