Yang Liu

US Patent:

20120321699, Dec 20, 2012

Filed:

Feb 25, 2011

Appl. No.:

13/581157

Inventors:

Barton F. Haynes - Durham NC, US
Georgia Tomaras - Durham NC, US
Thomas B. Kepler - Durham NC, US
Yang Liu - Durham NC, US
T. Matt Holl - Durham NC, US
Guang Yang - Durham NC, US
Garnett Kelsoe - Durham NC, US
Mattia Bonsignori - Durham NC, US

International Classification:

A61K 39/21
A61K 9/127
C07K 16/10
A61P 31/18

US Classification:

424450, 4242081, 42419611, 5303894

Abstract:

The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.

US Patent:

20180133319, May 17, 2018

Filed:

Dec 22, 2017

Appl. No.:

15/852598

Inventors:

- Durham NC, US
Brant A. Inman - Durham NC, US
Paolo Maccarini - Durham NC, US
Greg Palmer - Durham NC, US
Yang Liu - Durham NC, US
Douglas Weitzel - Durham NC, US

International Classification:

A61K 41/00
A61P 35/00
A61P 35/04
A61K 9/51
A61K 33/24
A61K 39/395
A61K 9/00
A61K 47/69
A61P 35/02
A61N 5/06
A61N 1/40
A61N 5/02
A61B 18/20
A61B 18/14
A61B 18/18

Abstract:

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.

US Patent:

20170081623, Mar 23, 2017

Filed:

Mar 17, 2015

Appl. No.:

15/126332

Inventors:

- Cambridge MA, US
- Raleigh NC, US
Yang Liu - Raleigh NC, US
Kelly Wiltberger - Durham NC, US
Haofan Peng - Cary NC, US
Rachel Ferguson - Morrisville NC, US

Assignee:

Biogen MA Inc. - Cambridge MA
North Carolina State University - Raleigh NC

International Classification:

C12M 1/107
B01F 3/04

Abstract:

Systems, devices, and methods for the delivery of gas bubbles to liquids are generally described. The devices can include a primary conduit () comprising a plurality of openings () fluidically connecting an internal flow pathway () of the primary conduit to an environment outside the primary conduit. The devices may also include, in some instances, a secondary conduit () located at least partially within the primary conduit, the secondary conduit configured to redistribute the pressure of the gas delivered to the openings of the primary conduit, and comprising a plurality of openings () fluidically connecting an internal flow pathway () of the secondary conduit to a portion of the internal flow pathway () of the primary conduit outside the secondary conduit. Certain of the gas delivery systems and methods described herein are capable of delivering gas at relatively uniform linear flow velocities across multiple gas outlet openings. Certain embodiments are related to inventive configurations (e.g., spacings and/or sizing) of gas outlet openings in one or more conduits of the gas delivery device (e.g., the primary conduit and/or, when present, the secondary conduit). In addition, some embodiments are related to inventive arrangements for joining a gas delivery device is to a vessel, which may be part of for example, a reactor such as a bioreactor. Certain embodiments are related to the orientation of the gas delivery device and/or its components (e.g., during operation).

US Patent:

20160271244, Sep 22, 2016

Filed:

Feb 29, 2016

Appl. No.:

15/056655

Inventors:

- Durham NC, US
Georgia Tomaras - Durham NC, US
Thomas B. Kepler - Durham NC, US
S. Munir Alam - Durham NC, US
Yang Liu - Durham NC, US
T. Matt Holl - Durham NC, US
Guang Yang - Durham NC, US
Garnett Kelsoe - Durham NC, US
Mattia Bonsignori - Durham NC, US

International Classification:

A61K 39/21
C07K 16/10
A61K 39/108

Abstract:

The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.