Edward Alan Goldberg

US Patent:

7738094, Jun 15, 2010

Filed:

Jan 22, 2008

Appl. No.:

12/009659

Inventors:

Edward Michael Goldberg - Redwood City CA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

G01N 1/10
G01N 33/48

US Classification:

356246, 356 39

Abstract:

The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label. System of the invention may further include a controller operationally associated with the one or more light sources for successively directing illumination beams onto the specimen so that each of the different differentially excitable labels is successively caused to emit an optical signal within the same wavelength band, an optical system capable of collecting such emitted optical signals and forming successive images corresponding to the labeled features of the specimen on a light-responsive surface to form successive sets of image data thereof, and a disposable cuvette for collection and optical analysis of non-red blood cells.

US Patent:

7816135, Oct 19, 2010

Filed:

Jun 26, 2008

Appl. No.:

12/215501

Inventors:

Edward Michael Goldberg - Redwood City CA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NY

International Classification:

C12N 5/08

US Classification:

435372, 435374

Abstract:

The invention provides methods and compositions for identifying and counting lymphocytes in a biological sample, such as whole blood, by means of a probe comprising at least one binding compound specific for a T lymphocyte-specific marker, e. g. a CD2 or CD3, and at least one binding compound specific for CD45RA. Lymphocytes within the sample combine with such a probe to form a distinguishable subpopulation based on the amount of probe that specifically binds to their surfaces, thereby permitting such lymphocytes to be detected and enumerated on the basis of the intensity of the signal generated by the probe, and without the need of a separate physical measurement, such as light scatter. With additional probes specific for additional blood cell markers, percentages of lymphocytes, monocytes and granulocytes in a sample may be determined.

US Patent:

8248597, Aug 21, 2012

Filed:

May 6, 2010

Appl. No.:

12/775333

Inventors:

Edward Michael Goldberg - Redwood City CA, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

G01N 1/10

US Classification:

356246

Abstract:

The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label. System of the invention may further include a controller operationally associated with the one or more light sources for successively directing illumination beams onto the specimen so that each of the different differentially excitable labels is successively caused to emit an optical signal within the same wavelength band, an optical system capable of collecting such emitted optical signals and forming successive images corresponding to the labeled features of the specimen on a light-responsive surface to form successive sets of image data thereof, and a disposable cuvette for collection and optical analysis of non-red blood cells.

US Patent:

20130045529, Feb 21, 2013

Filed:

Aug 20, 2012

Appl. No.:

13/590114

Inventors:

Edward Michael Goldberg - Redwood City CA, US
Jeffrey Brooker - Oak Hill VA, US

International Classification:

C12M 1/34
G01N 1/00

US Classification:

4352887, 422554

Abstract:

The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label.

US Patent:

58039147, Sep 8, 1998

Filed:

Oct 3, 1996

Appl. No.:

8/720896

Inventors:

Carl J. Ryals - Fremont CA
Stanley H. Wong - Cupertino CA
Edward M. Goldberg - Sunnyvale CA
Robert C. Hudson - San Jose CA

Assignee:

ADAC Laboratories - Milpitas CA

International Classification:

A61B 505

US Classification:

600407

Abstract:

A system for acquisition, processing and display of gated SPECT imaging data for use in diagnosing Coronary Artery Disease (CAD) in nuclear medicine. The present invention provides a physician with two parameters for evaluating CAD: information relating to the distribution of blood flow within the myocardium (perfusion) and information relating to myocardium wall motion (function). One aspect of the present invention provides the physician with a display of functional images representing quantitative information relating to both perfusion and function with respect to selected regions of interest of the subject heart at end-diastole and end-systole segments of the cardiac cycle. The functional display consists of arcs of varied width depending on wall motion and color coded to illustrate degrees of myocardial perfusion for different pie shaped sections of a selected region of interest within a given short axis slice of reconstructed volume data. The present invention also provides a series of display images allowing facilitated access, display, and comparison of the numerous image frames of the heart that may be collected during gated SPECT sessions. The present invention also offers the ability to define and recall parameter files representative of data acquisition and processing parameters and protocol for use in gated SPECT studies.

US Patent:

44590504, Jul 10, 1984

Filed:

Apr 21, 1982

Appl. No.:

6/370331

Inventors:

Edward M. Goldberg - Albany CA
Larry R. Herzberg - Boulder Creek CA

Assignee:

Chroma - San Jose CA

International Classification:

B41J 312

US Classification:

400121

Abstract:

A servo control system for the carriage of a matrix impact printer allows printing to occur during both acceleration and deceleration of the carriage. This is especially useful where the carriage is transporting several ribbon cartridges of different colors. In addition, printing may occur during the midrange portion of the carriage which is driven at a variable velocity to compensate for differences in printing and resolution requirements.

US Patent:

54311616, Jul 11, 1995

Filed:

Apr 15, 1993

Appl. No.:

8/048751

Inventors:

Carl J. Ryals - Fremont CA
Stanley H. Wong - Cupertino CA
Edward M. Goldberg - Sunnyvale CA
Robert C. Hudson - San Jose CA

Assignee:

ADAC Laboratories - Milpitas CA

International Classification:

A61B 505

US Classification:

1286531

Abstract:

A system for acquisition, processing and display of gated SPECT imaging data for use in diagnosing Coronary Artery Disease (CAD) in nuclear medicine. The present invention provides a physician with two parameters for evaluating CAD: information relating to the distribution of blood flow within the myocardium (perfusion) and information relating to myocardium wall motion (function). One aspect of the present invention provides the physician with a display of functional images representing quantitative information relating to both perfusion and function with respect to selected regions of interest of the subject heart at end-diastole and end-systole segments of the cardiac cycle. The functional display consists of arcs of varied width depending on wall motion and color coded to illustrate degrees of myocardial perfusion for different pie shaped sections of a selected region of interest within a given short axis slice of reconstructed volume data. The present invention also provides a series of display images allowing facilitated access, display, and comparison of the numerous image frames of the heart that may be collected during gated SPECT sessions. The present invention also offers the ability to define and recall parameter files representative of data acquisition and processing parameters and protocol for use in gated SPECT studies.