Jay Schneider - Coppell TX, US Jenny Hsieh - Irving TX, US Douglas Frantz - Flower Mound TX, US Steven L. McKnight - Dallas TX, US Joseph M. Ready - Carrollton TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 31/422 C07D 261/18
US Classification:
514378, 548248
Abstract:
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Stem Cell Differentiating Agents And Uses Therefor
Eric N. Olson - Dallas TX, US Douglas Frantz - Boerne TX, US Jenny Hsieh - Irving TX, US Steven L. McKnight - Dallas TX, US Jay Schneider - Coppell TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
Stem Cell Differentiating Agents And Uses Therefor
Eric Olson - Dallas TX, US Douglas Frantz - Flower Mound TX, US Jenny Hsieh - Irving TX, US Steven L. McKnight - Dallas TX, US Jay Schneider - Coppell TX, US
The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
Jay Schneider - Coppell TX, US Jenny Hsieh - Irving TX, US Douglas Frantz - Flower Mound TX, US Steven L. McKnight - Dallas TX, US Joseph M. Ready - Carrollton TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Stem Cell Differentiating Agents And Uses Therefor
The Board of Regents of the University of Texas - Austin TX, US Douglas FRANTZ - Boerne TX, US Jenny HSIEH - Irving TX, US Steven L. MCKNIGHT - Dallas TX, US Jay SCHNEIDER - Coppell TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C07D 413/04 C12N 5/071
US Classification:
514378, 435377
Abstract:
The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
- Austin TX, US Jenny Hsieh - Irving TX, US Douglas Frantz - Flower Mound TX, US Steven L. McKnight - Dallas TX, US Joseph M. Ready - Carrollton TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C07D 413/04 C12N 5/079 C07D 261/18
US Classification:
514378, 435377
Abstract:
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
Jenny Hsieh, a professor in the Department of Biology at UTSA, led the research to test the teams questions. She said researchers took human stem cells and created brain organoids, or tiny brains, in a lab.