Robert Gang Luo

US Patent:

6365147, Apr 2, 2002

Filed:

Oct 13, 1999

Appl. No.:

09/416934

Inventors:

Robert Gang Luo - Edison NJ
Yun Kang - Harrison NJ

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

A01N 6300

US Classification:

424 931, 604 502, 210661, 210670, 210691, 210692

Abstract:

The present invention relates to methods for depleting endotoxin from biological solutions by exposure of solutions containing endotoxin to an immobilized metal affinity chromatography matrix composed of a metal ion such as iron (III) bounds to a resin, wherein the metal is capable of selectively binding endotoxin in the solution. These methods are useful for purifying, for example, biological products prepared using bacterial cells, or products in which bacterial contamination is problematic. In another embodiment, endotoxin in circulation in a body can be removed by exposing the blood to the aforementioned matrix, whereby endotoxin is removed before the blood is returned to the body.

US Patent:

6986847, Jan 17, 2006

Filed:

May 12, 2003

Appl. No.:

10/436353

Inventors:

Kamalesh K. Sirkar - Bridgewater NJ, US
Robert G. Luo - Boyds MD, US
Yanke Xu - Bound Brook NJ, US
Xiao-Ping Dai - Flemington NJ, US

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

B01D 61/18
B01D 15/08

US Classification:

210650, 2101982, 2103216, 21032189, 210506, 210656, 427245

Abstract:

An apparatus and method for recovering bioproducts from a feed solution. In one embodiment, the apparatus includes a module housing, a membrane means disposed in the housing for filtering the bioproducts from the feed solution wherein a portion of the membrane means is coated with a polymeric coating, and an adsorbent bed disposed in the housing for retaining the bioproducts which permeate through the membrane, wherein the apparatus is adapted to allow fractionation and purification of the retained bioproducts from the bed by elution.

US Patent:

60224770, Feb 8, 2000

Filed:

Nov 14, 1997

Appl. No.:

8/970986

Inventors:

Robert G. Luo - Edison NJ
Kamalesh K. Sirkar - Berkeley Heights NJ

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

B01D 1100
B01D 1508

US Classification:

210645

Abstract:

An apparatus and method for recovering bioproducts from a feed solution. In one embodiment, the apparatus includes a module housing, a membrane disposed in the housing for filtering the bioproducts from the feed solution, and an adsorbent bed disposed in the housing for retaining the bioproducts which permeate through the membrane, wherein the apparatus is adapted to allow fractionation and purification of the retained bioproducts from the bed by elution.

US Patent:

20210338557, Nov 4, 2021

Filed:

Jan 4, 2019

Appl. No.:

17/294532

Inventors:

- Suffern NY, US
John W. LYGA - Basking Ridge NJ, US
Robert Zhiyong LUO - New City NY, US

International Classification:

A61K 8/64
A61K 8/365
A61K 8/67
A61K 8/34
A61K 8/46
A61Q 19/08

Abstract:

Peptides (and derivatives thereof), topical compositions, and methods of diminishing signs of aging and/or improving health of human integuments are provided. The peptides are derived from human Growth Differentiation Factor 11 (GDF-11) and typically have one or more chemical modifications of the amino acid residues. Preferred modifications of GDF-11 fragments include methionine oxidation.

US Patent:

20170304306, Oct 26, 2017

Filed:

Sep 8, 2015

Appl. No.:

15/510047

Inventors:

- NORTH BRUNSWICK NJ, US
Olga BABICH - Cranford NJ, US
Tina GARYANTES - Warren NJ, US
Robert Z. LUO - New City NY, US
Srinivasan P. Venkatachalan - Monmouth Junction NJ, US

Assignee:

CHROMOCELL CORPORATION - NORTH BRUNSWICK NJ

International Classification:

A61K 31/519
A61K 31/4439
A61K 31/433
A61K 31/454
A61K 31/426

Abstract:

Provided herein are methods for treating or preventing prediabetes or diabetes, or maintaining or lowering blood or plasma glucose or maintaining or lowering blood or plasma glycated hemoglobin comprising administering to a subject in need thereof a therapeutically effective amount of a compound selectively inhibiting NaV1.7. In particular, provided herein are processes for the preparation of and intermediates used in the preparation of compounds selectively inhibiting NaV 1.7, such as the compounds of Formula I or compounds of Formula I′:

US Patent:

20160221974, Aug 4, 2016

Filed:

Sep 9, 2014

Appl. No.:

15/021153

Inventors:

- North Brunswick NJ, US
Tina GARYANTES - Warren NJ, US
Robert Z. LUO - New City NY, US
David J. PALLING - Glen Ridge NJ, US
Srinivasan P. VENKATACHALAN - Monmouth Junction NJ, US

Assignee:

CHROMOCELL CORPORATION - North Brunswick NJ

International Classification:

C07D 277/52
C07D 471/04
C07D 487/04
C07D 417/12
C07D 285/08

Abstract:

Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I′:In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.

US Patent:

20160130239, May 12, 2016

Filed:

Jan 13, 2016

Appl. No.:

14/994846

Inventors:

- North Brunswick NJ, US
Tina GARYANTES - Warren NJ, US
Robert Z. LUO - New City NY, US
David J. PALLING - Glen Ridge NJ, US
Srinivasan P. VENKATACHALAN - Monmouth Junction NJ, US

Assignee:

CHROMOCELL CORPORATION - North Brunswick NJ

International Classification:

C07D 277/52

Abstract:

Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I′:In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.