Xinzhan A Peng from 4899 Bridle Ridge Ct, San Diego, CA 92130, age 58, Phone: 7608519971

Resumes

Senior Staff Scientist

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Location:

San Diego, CA

Industry:

Biotechnology

Work:

Life Technologies since Apr 2010
Senior Staff Scientist
Life Technologies Oct 2008 - Mar 2010
Senior Scientist
LI-COR Biosciences Jan 2004 - Oct 2008
Senior Scientist
LI-COR Biosciences Jul 2001 - Dec 2003
Scientist
Nanjing University of Technology Feb 1991 - Jun 1996
Lecturer

Education:

Case Western Reserve University 1996 - 2001
Ph. D., Chemistry Nanjing University of Technology 1988 - 1991
MS, Materials Engineering Nanjing University of Technology 1984 - 1988
BS, Materials Engineering

Skills:

Fluorescence Microscopy
Pcr
Fluorescence
Assay Development
Dna Sequencing
Dna
High Throughput Screening
Microscopy
Sequencing
Genomics
Molecular Biology
Biotechnology
Cell
Lifesciences
Protein Chemistry
Biochemistry
Proteomics
Protein Purification
Genetics
Cell Biology
Flow Cytometry
Hplc
Mass Spectrometry
Uv/Vis
Purification
Qpcr
Drug Discovery
Immunoassays

Us Patents

Cyanine Dyes And Methods Of Use
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US Patent:

8227621, Jul 24, 2012
Filed:

Jun 12, 2006
Appl. No.:

11/423675
Inventors:

Xinzhan Peng - Lincoln NE, US
Xinshe Xu - Lincoln NE, US
Daniel R. Draney - Lincoln NE, US
Garrick M. Little - Lincoln NE, US
Jiyan Chen - Lincoln NE, US
William M. Volcheck - Lincoln NE, US
Charles Prescott - Lincoln NE, US
Assignee:

Li-Cor, Inc. - Lincoln NE
International Classification:

C07D 209/56
A61B 5/00
US Classification:

548427, 424 96
Abstract:

The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.

Conjugates Of Biomolecules To Nanoparticles
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US Patent:

8603792, Dec 10, 2013
Filed:

Mar 26, 2010
Appl. No.:

12/748355
Inventors:

Theo Nikiforov - Carlsbad CA, US
Daniel Mazur - San Diego CA, US
Xinzhan Peng - Carlsbad CA, US
Yuri Belosludtsev - The Woodlands TX, US
Howard Reese - Poway CA, US
Dmitriy Gremyachinskiy - Eugene OR, US
Roman Rozhkov - Eugene OR, US
John M. Mauro - Eugene OR, US
Joseph Beechem - Eugene OR, US
Eric Tulsky - Eugene OR, US
Imad Naasani - Manchester, GB
Kari Haley - Eugene OR, US
Joseph A. Treadway - Eugene OR, US
Assignee:

Life Technologies Corporation - Carlsbad CA
International Classification:

C12N 9/12
US Classification:

435194, 977773, 514 2
Abstract:

Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced aggregation and improved stochiometries wherein the average biomolecule:nanoparticle ratio approaches or equals 1:1. Also disclosed herein are improved methods for preparing such conjugates, and methods and systems for using such conjugates in biological applications such as nucleotide incorporation, primer extension and single molecule sequencing.

Phthalocyanine Dyes
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US Patent:

20040171827, Sep 2, 2004
Filed:

Oct 23, 2003
Appl. No.:

10/693300
Inventors:

Xinzhan Peng - Lincoln NE, US
Daniel Draney - Lincoln NE, US
Jiyan Chen - Lincoln NE, US
Assignee:

LI-COR, Inc. - Lincoln NE
International Classification:

C07D487/22
US Classification:

540/145000
Abstract:

Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high quantum yield, and are useful in bioassays.

Methods And Apparatus For Single Molecule Sequencing Using Energy Transfer Detection
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US Patent:

20100255487, Oct 7, 2010
Filed:

Mar 26, 2010
Appl. No.:

12/748168
Inventors:

JOSEPH BEECHEM - EUGENE OR, US
THEO NIKIFOROV - CARLSBAD CA, US
Vi-En Choong - Carlsbad CA, US
Xinzhan Peng - Carlsbad CA, US
Guobin Luo - Oceanside CA, US
Cheng-Yao Chen - Carlsbad CA, US
Michael Previte - Carlsbad CA, US
Assignee:

LIFE TECHNOLOGIES CORPORATION - CARLSBAD CA
International Classification:

C12Q 1/68
C12N 9/10
US Classification:

435 6, 435193
Abstract:

Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.

Polymerase Compositions & Methods
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US Patent:

20110014612, Jan 20, 2011
Filed:

Mar 26, 2010
Appl. No.:

12/748359
Inventors:

STEPHEN P. HENDRICKS - LOS GATOS CA, US
MICHAEL PHELAN - HAYWARD CA, US
MARIAN PERIS - BELMONT CA, US
CHENG-YAO CHEN - CARLSBAD CA, US
DANIEL MAZUR - SAN DIEGO CA, US
XINZHAN PENG - CARLSBAD CA, US
AMY CASTILLO - HOUSTON TX, US
Assignee:

LIFE TECHNOLOGIES CORPORATION - CARLSBAD CA
International Classification:

C12Q 1/68
C12P 19/34
C12N 9/12
C12N 5/10
C12N 15/63
C07H 21/04
US Classification:

435 6, 435 911, 435194, 435325, 4353201, 536 232
Abstract:

Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.

Polymerase Compositions And Methods
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US Patent:

20120322057, Dec 20, 2012
Filed:

Jul 3, 2012
Appl. No.:

13/540935
Inventors:

Stephen P. HENDRICKS - Los Gatos CA, US
Michael PHELAN - Hayward CA, US
Marian PERIS - Belmont CA, US
Cheng-Yao CHEN - Carlsbad CA, US
Daniel MAZUR - San Diego CA, US
Xinzhan PENG - Carlsbad CA, US
Amy CASTILLO - Houston TX, US
Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:

C12N 9/12
C12Q 1/68
C12N 1/00
C12P 19/34
C12N 15/54
C12N 15/63
US Classification:

435 61, 435194, 536 232, 435243, 435 915
Abstract:

Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.

Methods And Apparatus For Single Molecule Sequencing Using Energy Transfer Detection
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US Patent:

20120329042, Dec 27, 2012
Filed:

Jul 30, 2012
Appl. No.:

13/562159
Inventors:

Joseph BEECHEM - Eugene OR, US
Theo NIKIFOROV - Carlsbad CA, US
Vi-En CHOONG - Carlsbad CA, US
Xinzhan PENG - Carlsbad CA, US
Guobin LUO - Oceanside CA, US
Cheng-Yao CHEN - Carlsbad CA, US
Michael PREVITE - Carlsbad CA, US
Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:

G01N 21/64
US Classification:

435 61
Abstract:

Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.

Library Preparation Methods And Compositions And Uses Therefor
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US Patent:

20220315917, Oct 6, 2022
Filed:

May 10, 2021
Appl. No.:

17/302674
Inventors:

- Carlsbad CA, US
Daniel MAZUR - San Diego CA, US
Sihong CHEN - Vista CA, US
Guobin LUO - Oceanside CA, US
Xinzhan PENG - San Diego CA, US
International Classification:

C12N 15/10
C12Q 1/6806
C12Q 1/6853
C12Q 1/6855
Abstract:

Provided are methods for preparing a library of target nucleic acid sequences, as well as compositions and uses therefor. Methods comprise contacting a nucleic acid sample with a plurality of adaptors capable of amplification of one or more target nucleic acid sequences under conditions wherein the target nucleic acid(s) undergo a first amplification; digesting the resulting first amplification products; repairing the digested target amplicons; and amplifying the repaired products in a second amplification, thereby producing a library of target nucleic acid sequence. Each of the plurality of adaptor compositions comprise a handle and a targeted nucleic acid sequence and optionally one or more tag sequences. Provided methods may be carried out in a single, addition only workflow reaction, allowing for rapid production of highly multiplexed targeted libraries, optionally including unique tag sequences. Resulting library compositions are useful for a variety of applications, including sequencing applications.